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Definition
 
enEnglish
Exotropia definition: A form of ocular misalignment where the visual axes diverge inappropriately. For example, medial rectus muscle weakness may produce this condition as the affected eye will deviate laterally upon attempted forward gaze. An exotropia occurs due to the relatively unopposed force exerted on the eye by the lateral rectus muscle, which pulls the eye in an outward direction.
DNA Mismatch Repair Protein MSH3 definition: DNA Mismatch Repair Protein MSH3, encoded by the MSH3 gene (MutS family), is a 127-kD mismatch repair (MMR) protein. Mismatch recognition in human cells is mediated by two heterodimers, MutS alpha (MSH2/MSH6) and MutS beta (MSH2/MSH3) with different mispair recognition properties and abilities. Both participate in repair of a dinucleotide insertion-deletion heterology but only MutS alpha restores base-base mismatch repair and shoulders primary responsibility for mismatch correction during replication. Predisposition to intestinal cancer requires loss of function of both Msh2/Msh6 and Msh2/Msh3 but Msh3 deficiency alone does not cause cancer predisposition. Mismatch repair deficiency can arise not only through mutation or transcriptional silencing of a mismatch repair gene, but also as a result of imbalance in the relative amounts of the MSH3 and MSH6 proteins because MutS alpha and MutS beta share a common component, MSH2. (NCI)
Neuregulin 2 definition: Encoded by human NRG2 Gene (NRG Family), variant type I membrane or soluble growth factor Neuregulin 2 proteins (422-858-aa, 91.7-kD precursor) contain an N-terminal domain, an Ig-C2 loop, an EGF-like domain, a transmembrane sequence, and a large cytoplasmic tail with potential N-linked and O-linked glycosylation sites. The membrane-bound form seems to be inactive and the cytoplasmic domain may regulate trafficking and proteolytic processing (by dimerization). Like Neuregulin 1, Neuregulin 2 binds to transmembrane ERBB3 and ERBB4 tyrosine kinase receptors, recruits ERBB1 and ERBB2 coreceptors, and induces receptor activation. ERBB receptor binding may involve entirely the EGF-like domain. Found primarily in the nervous system, Neuregulin 2 induces growth and differentiation of epithelial, neuronal, glial, and other cell types. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Neuregulin 2 definition: Neuregulin-2, a novel neuregulin-1-like molecule encoded by a distinct gene. Like neuregulin-1, neuregulin-2 also binds to ErbB3 and ErbB4, although it appears to signal distinctly, perhaps by activating different receptor heterodimers. Neuregulin-2 is primarily found in granule cells in the cerebellum, hippocampus, and olfactory bulb.
MSH3 Gene definition: This gene plays a role in DNA mismatch repair and has been implicated in several cancers.
NRG2 Gene definition: This gene is involved in cellular differentiation, growth and proliferation.
divergent definition: [1] divergierend [2] auseinandergehend, auseinanderlaufend [3] abweichend
 
deGerman
divergent definition: [1] sich voneinander entfernend, unterschiedlich verlaufend [2] Mathematik: keinen Grenzwert aufweisend (absolut, grammatikalisch
 
frFrench
divergent definition: Partie d'une tuyère de section croissante, en aval du col, où se produit la détente du gaz.
 
Publications
 

Murine Stat2 is uncharacteristically divergent.

C Park et al.

Nucleic Acids Research , 01 Nov 1999

Divergent Selection on Opsins Drives Incipient Speciation in Lake Victoria Cichlids

Yohey Terai et al.

PLoS Biology , 01 Dec 2006

Detection of divergent genes in microbial aCGH experiments

Lars Snipen et al.

BMC Bioinformatics , 30 Mar 2006

Divergent Selection and the Evolution of Signal Traits and Mating Preferences

Howard D Rundle et al.

PLoS Biology , 01 Nov 2005

The constancy of gene conservation across divergent bacterial orders

Olin K Silander et al.

BMC Research Notes , 07 Jan 2009

DNA bending and expression of the divergent nagE-B operons.

J Plumbridge et al.

Nucleic Acids Research , 01 Mar 1998

Divergent genes for translation initiation factor eIF-4A are coordinately expressed in tobacco.

G W Owttrim et al.

Nucleic Acids Research , 25 Oct 1991

The regulatory region of the divergent argECBH operon in Escherichia coli K-12.

J Piette et al.

Nucleic Acids Research , 20 Dec 1982

Demonstration of a divergent transcript from the bidirectional heavy chain immunoglobulin promoter VH441 in B-cells.

Q T Nguyen et al.

Nucleic Acids Research , 11 Oct 1991

The role of immunohistochemistry in medullomyoblastoma – a case series highlighting divergent differentiation

Man Updesh S Sachdeva et al.

Diagnostic Pathology , 25 Apr 2008

681 further publications >>