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Translation
 
enEnglish deGerman
1 word
all-dominant alles beherrschend
all-dominant alles bestimmend
dominant Dominante
dominant Ober-
dominant beherrschend
dominant bestimmend
dominant dominant
dominant emporragend
dominant herrschend
dominant höher
13 further results >>
 
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enEnglish esSpanish
1 word
dominant más alto
dominant superior
2 words
(pre)dominant culture civilización dominante
 
enEnglish fiFinnish
2 words
(pre)dominant culture johtokulttuuri
 
enEnglish itItalian
1 word
dominant superiore
2 words
(pre)dominant culture cultura dominante
 
enEnglish afAfrikaans
1 word
dominant allesbeheersend
 
enEnglish caCatalan
1 word
dominant superior
 
enEnglish csCzech
1 word
dominant dominantní
 
enEnglish elGreek
1 word
dominant ηγεμόνας|R=iyemónas
 
enEnglish eoEsperanto
1 word
dominant supera
dominant superrega
dominant supra
dominant suverena
dominant suvereno
 
enEnglish frFrench
1 word
dominant dominant
dominant dominante
dominant souverain
dominant supérieur
 
enEnglish idIndonesian
1 word
dominant kedaulatan
dominant unggul
 
enEnglish ioIdo
1 word
dominant supera
dominant superiora
dominant superioro
dominant suvereno
 
enEnglish nlDutch
1 word
dominant allesbeheersend
dominant boven-
dominant bovenste
dominant oppermachtig
dominant opperste
dominant prevalent
dominant soeverein
dominant superieur
 
enEnglish plPolish
1 word
dominant wyższy
 
enEnglish ptPortuguese
1 word
dominant soberano
dominant superior
 
enEnglish ruRussian
1 word
dominant высщий
 
enEnglish sqAlbanian
1 word
dominant epërm
 
enEnglish svSwedish
1 word
dominant suverän
 
frFrench enEnglish
1 word
dominant dominant
 
frFrench csCzech
1 word
dominant dominantní
 
deGerman enEnglish
1 word
dominant dominant
dominant dominantly
 
Definition
 
enEnglish
Genes, Dominant definition: Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.
Machado-Joseph Disease definition: A dominantly-inherited ATAXIA first described in people of Azorean and Portuguese descent, and subsequently identified in Brazil, Japan, China, and Australia. This disorder is classified as one of the SPINOCEREBELLAR ATAXIAS (Type 3) and has been associated with a mutation of the MJD1 gene on chromosome 14. Clinical features include progressive ataxia, DYSARTHRIA, postural instability, nystagmus, eyelid retraction, and facial FASCICULATIONS. DYSTONIA is prominent in younger patients (referred to as Type I Machado-Joseph Disease). Type II features ataxia and ocular signs; Type III features MUSCULAR ATROPHY and a sensorimotor neuropathy; and Type IV features extrapyramidal signs combined with a sensorimotor neuropathy. (From Clin Neurosci 1995;3(1):17-22; Ann Neurol 1998 Mar;43(3):288-96)
Polycystic Kidney, Autosomal Dominant definition: Kidney disorders with autosomal dominant inheritance and characterized by multiple CYSTS in both KIDNEYS with progressive deterioration of renal function.
Opitz syndrome (OS) definition: First reported as two separate disorders, the G syndrome and the BBB syndrome, the condition is now considered a single entity with a wide clinical variability, ranging from neonatal lethality to an asymptomatic form. Widely-spaced inner ocular canthi and hypospadias as the major features of this syndrome. Associated disorders may include craniofacial anomalies, congenital heart defects, laryngotracheal disorders with dysphagia and aspiration, developmental delay, and other abnormalities. Most symptoms occur in both genetically determined forms, except for anteverted nares and posterior pharyngeal cleft which are found only in X-linked families. The acronym BBB stands for the initials of the last names of each of the three originally reported families. Opitz described the G syndrome, also named after the affected family, consisting of apparent hypertelorism, mild downslanting of the palpebral fissures, epicanthal folds, hypospadias, and laryngotracheoesophageal defects.
autosomal dominant trait definition: full phenotypic expression of a gene carried on the paired autosomes, in both heterozygotes and homozygotes.
benign familial macrocephaly (BFM) definition: A benign form of macrocephaly, sometimes identified with Sotos syndrome, with normal or near-normal birth weight and length with subsequent obesity, variable developmental delay, and typical square facies with frontal bossing, dished-out midface, biparietal narrowing, and long philtrum.
Optic Atrophy, Autosomal Dominant definition: Dominant optic atrophy is a hereditary optic neuropathy causing decreased visual acuity, color vision deficits, a centrocecal scotoma, and optic nerve pallor (Hum. Genet. 1998; 102: 79-86). Mutations leading to this condition have been mapped to the OPA1 gene at chromosome 3q28-q29. OPA1 codes for a dynamin-related GTPase that localizes to mitochondria.
Hyperlipoproteinemia Type IIa definition: Hypercholesterolemia that is caused by mutation in the LOW DENSITY LIPOPROTEIN RECEPTOR gene. This receptor defect prevents LDL binding to the cell membrane and uptake of cholesterol which normally suppresses further cholesterol synthesis.
Dominant-Negative Mutation definition: A dominant-negative mutation produces a mutant gene product that can inhibit the function of the wild-type gene product in heterozygotes.
Dominant definition: Exercising influence or control.
7 further definitions >>
deGerman
Leitkultur definition: [1] Diejenige Kultur (im Sinne von Sprache, Sitten und Gebräuche, Werte), die in einer Region oder in einem Land dominant und richtungsangebend ist, weil sie entweder die örtlich angestammte ist oder die von der Mehrheit der Einwohner praktizierte.
dominant definition: [1] beherrschend [2] Biologie, Genetik: sich in der Merkmalsausprägung durchsetzend
 
frFrench
dominante definition: Note qui fait la quinte au-dessus de la note tonique ou fondamentale.
souverain definition: Celui, celle qui possède, en qui réside l’autorité souveraine.
souverain definition: Prince souverain, monarque.
souverain definition: Monnaie d’or d’Angleterre qui valait une livre sterling.
supérieur definition: Celui, celle qui a autorité sur un autre, qui a le droit de commander à un autre.
supérieur definition: Dans les maisons religieuses,
 
Examples
 

Countermeasures against such dominant-negative or dominant-inhibitory action might include the evolutionary gain of novel, transactivation-independent tumor suppressor functions by the wild-type monomer.

Kristina Heyne et al.

Molecular Cancer 7 (7), 12 Jun 2008

Here we have studied, mostly in human HCT116 colon adenocarcinoma cells with an intact p53 pathway, the effects of dominant-inhibitory p53 mutants and of Δex2/3p73, a tumor-associated ΔTA-competitor of wild-type p53, on the nuclear transactivation-dependent and extra-nuclear transactivation-independent functions of wild-type p53.

Kristina Heyne et al.

Molecular Cancer 7 (7), 12 Jun 2008

The extra-nuclear p53-dependent apoptosis may constitute a fail-safe mechanism against dominant inhibition.

Kristina Heyne et al.

Molecular Cancer 7 (7), 12 Jun 2008

Apart from exhibiting a wt p53-independent oncogenic 'gain-of-function', which at least in part seems to be mediated through inactivating interaction with other pro-apoptotic members of the p53 family (reviewed in [ 17 ]), studies of Li-Fraumeni individuals with an inherited mutated allele and of knock-in mice have clearly indicated that mutant proteins can act dominant-inhibitory, either through hetero-oligomerization with wt p53 expressed from the second allele or through the sequestration of limiting factors [ 18 , 19 ].

Kristina Heyne et al.

Molecular Cancer 7 (7), 12 Jun 2008

Another potent mechanism of dominant inhibition seems to employ target gene promoter occupation by transactivation-incompetent (ΔN and ΔTA-) members of the p53 family.

Kristina Heyne et al.

Molecular Cancer 7 (7), 12 Jun 2008

1261 further examples >>
Publications
 

Resistance of mitochondrial p53 to dominant inhibition

Kristina Heyne et al.

Molecular Cancer , 12 Jun 2008

Induction of dominant mutations that cause skeletal malformations in mice

Paul B. Selby

Environmental Health Perspectives , 01 Jun 1978

Trans-dominant inhibition of transcription activator LFB1.

A Nicosia et al.

Nucleic Acids Research , 25 Oct 1992

Analysis of dominant copy number mutants of the plasmid pMB1.

L Castagnoli et al.

Nucleic Acids Research , 25 Jul 1985

Age-Related Attenuation of Dominant Hand Superiority

Tobias Kalisch et al.

PLoS ONE , 20 Dec 2006

Mitochondrial oxidative phosphorylation in autosomal dominant optic atrophy

Vladimir I Mayorov et al.

BMC Biochemistry , 10 Sep 2008

Allelic Heterogeneity at the Equine KIT Locus in Dominant White ( W ) Horses

Bianca Haase et al.

PLoS Genetics , 01 Nov 2007

Differences in the evolutionary history of disease genes affected by dominant or recessive mutations

Simon J Furney et al.

BMC Genomics , 03 Jul 2006

EDAR mutation in autosomal dominant hypohidrotic ectodermal dysplasia in two Swedish families

Lisbet K Lind et al.

BMC Medical Genetics , 24 Nov 2006

Autosomal dominant hereditary spastic paraplegia: Novel mutations in the REEP1 gene (SPG31)

Katharina J Schlang et al.

BMC Medical Genetics , 21 Jul 2008

1256 further publications >>