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Definition
 
enEnglish
interleukin-12 gene definition: The DNA sequence that encodes the protein cytokine interleukin-12 (IL-12). When introduced as the complementary DNA (cDNA) form into tumor cells by, for example, a genetically engineered adenovirus vector, the transfected IL-12 cDNA expresses IL-12 which activates antitumoral natural killer (NK) cells and CD8+ T-cells and stimulates the secretion of interferon-gamma (IFN-gamma), potentially inhibiting tumor cell metastasis. This gene therapy may also result in IL-12-mediated inhibition of vascular endothelial growth factor (VEGF) and enhancement of matrix metalloproteinases (MMPs). Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43632&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43632&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2222" NCI Thesaurus)
Interleukin-12 Gene definition: The DNA sequence that encodes the protein cytokine interleukin-12 (IL-12). When introduced as the complementary DNA (cDNA) form into tumor cells by, for example, a genetically engineered adenovirus vector, the transfected IL-12 cDNA expresses IL-12 which activates antitumoral natural killer (NK) cells and CD8+ T-cells and stimulates the secretion of interferon-gamma (IFN-gamma), potentially inhibiting tumor cell metastasis. This gene therapy may also result in IL-12-mediated inhibition of vascular endothelial growth factor (VEGF) and enhancement of matrix metalloproteinases (MMPs). (NCI04)
unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor definition: OBSOLETE (was not defined before being made obsolete). [GOC:mah]
unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase definition: OBSOLETE (was not defined before being made obsolete). [GOC:mah]
rMVA-PSA/PSMA/TRICOM definition: A cancer vaccine consisting of recombinant modified vaccinia Ankara (rMVA) encoding the prostate specific antigen (PSA), the prostate-specific membrane antigen (PSMA) and a TRIad of COstimulatory Molecules (B7-1, ICAM-1 and LFA-3) (TRICOM). Vaccination with PSA/PSMA in combination with TRICOM may enhance antigen presentation, resulting in the augmentation of a cytotoxic T cell (CTL) immune response against tumor cells over-expressing PSA or PSMA.
MVA-MUC1-IL2 Vaccine definition: A bivalent cancer vaccine comprised of a modified vaccinia virus Ankara (MVA) strain encoding human mucin 1 (MUC1) and interleukin-2 (IL-2) with potential immunostimulating and antineoplastic activities. Originally developed for the eradication of smallpox, MVA is a highly attenuated and replication-defective strain incapable of virion assembly and exerts potent immunostimulatory activity against antigens. Vaccination with MVA-MUC1-IL2 vaccine may stimulate the host immune system to mount a humoral and cytotoxic T lymphocyte (CTL) responses against tumor cells expressing MUC1, a tumor associated antigen, resulting in tumor cell lysis. Expression of IL-2 augments the specific CTL response against MUC1 expressing cells.
Adenovector Encoding MDA7 definition: A nonreplicating adenoviral vector (adenovector) encoding the melanoma differentiation-associated 7 gene (MDA7) with potential antineoplastic activity. After intratumoral injection and adenovector-mediated gene transfer of MDA7 into tumor cells, the expressed MDA7 transgene may inhibit tumor cell proliferation and induce tumor cell apoptosis.
adenovector encoding MDA7 definition: A nonreplicating adenoviral vector (adenovector) encoding the melanoma differentiation-associated 7 gene (MDA7) with potential antineoplastic activity. After intratumoral injection and adenovector-mediated gene transfer of MDA7 into tumor cells, the expressed MDA7 transgene may inhibit tumor cell proliferation and induce tumor cell apoptosis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=441241&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=441241&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48368" NCI Thesaurus)
Oncolytic Adenovirus Encoding GM-CSF definition: A recombinant oncolytic adenovirus encoding the immunohematopoietic cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with potential antineoplastic activity. Upon administration, the oncolytic adenovirus selectively infects and replicates in tumor cells, which may result in tumor cells lysis. Synergistically, GM-CSF (sargramostim) expressed by the oncolytic adenovirus may promote a cytotoxic T cell response against tumor cells harboring the oncolytic adenovirus, resulting in an immune-mediated tumor cell death.
oncolytic adenovirus encoding GM-CSF definition: A recombinant oncolytic adenovirus encoding the immunohematopoietic cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with potential antineoplastic activity. Upon administration, the oncolytic adenovirus selectively infects and replicates in tumor cells, which may result in tumor cells lysis. Synergistically, GM-CSF (sargramostim) expressed by the oncolytic adenovirus may promote a cytotoxic T cell response against tumor cells harboring the oncolytic adenovirus, resulting in an immune-mediated tumor cell death. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=434519&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=434519&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=" NCI Thesaurus)
16 further definitions >>
deGerman
Kodierung definition: [1] allgemein: Verschlüsselung von Botschaften mit Hilfe eines Codes; Abfassung einer Botschaft in einem bestimmten Code. [2] Linguistik: Teil eines Kommunikationsmodells: Prozess der "Versprachlichung" einer Nachricht auf allen sprachlichen Ebenen (phonetisch/ phonologisch, grammatisch, semantisch) durch den Sprecher oder Schreiber; Umsetzung dessen, was er ausdrücken will, in sprachliche Formen.
 
frFrench
encodage definition: Transcription de données vers un format ou un protocole codé.
 
Publications
 

An Information Theoretic Characterisation of Auditory Encoding

Tobias Overath et al.

PLoS Biology , 01 Nov 2007

Neuron participation in a synchrony-encoding assembly

Florence Duret et al.

BMC Neuroscience , 27 Oct 2006

Automatic medical encoding with SNOMED categories

Patrick Ruch et al.

BMC Medical Informatics and Decision Making , 27 Oct 2008

MicroRNA-encoding long non-coding RNAs

Shunmin He et al.

BMC Genomics , 21 May 2008

A chloroplast gene encoding a protein with one zinc finger.

Y Sasaki et al.

Nucleic Acids Research , 11 Aug 1989

Characterisation of mRNAs encoding the precursor for human apolipoprotein CI.

T J Knott et al.

Nucleic Acids Research , 11 May 1984

Characterization of amplified intracisternal A-particle elements encoding integrase.

K K Lueders et al.

Nucleic Acids Research , 25 Nov 1989

Frequent rearrangements of rRNA-encoding chromosomes in Giardia lamblia.

S M Le Blancq et al.

Nucleic Acids Research , 25 Aug 1991

Retinal Encoding of Ultrabrief Shape Recognition Cues

Ernest Greene

PLoS ONE , 12 Sep 2007

The mRNA and RNA-copy pseudogenes encoding TM30nm, a human cytoskeletal tropomyosin.

A R MacLeod et al.

Nucleic Acids Research , 11 Nov 1986

3295 further publications >>