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endocrine pancreas development definition: The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. [GOC:cvs]

Pdx-1 or Pdx-1-VP16 protein transduction induces β-cell gene expression in liver-stem WB cells: ... into pancreatic endocrine precursor cells. High glucose conditions were necessary for further differentiation into functional insulin-producing cells. Pdx-1 has the ability to permeate different cell types due to an inherent protein transduction domain (PTD). In this study, we evaluated liver-to-pancreas conversion of WB cells following Pdx-1 or Pdx-1-VP16 protein transduction. Findings WB cells were grown in high glucose medium containing Pdx-1 or Pdx-1-VP16 recombinant proteins for two weeks. β-like cell commitment was analysed by RT-PCR of pancreatic endocrine genes. We found that WB cells in high glucose culture spontaneously express pancreatic endocrine genes ( Pdx-1, Ngn3, Nkx2.2, Kir6.2 ). Their further differentiation into β-like cells expressing genes related to endocrine pancreas development ( Ngn3, NeuroD, Pax4, ...

Juliette Cuvelier Delisle et al.

BMC Research Notes , 09 Jan 2009

Expression of Groucho/TLE proteins during pancreas development: ... cell types during endocrine cell maturation. Of note, Tle2 and Tle3 are co-expressed with Gro/TLE interaction domain containing transcription factors that are essential for endocrine pancreas development. We further demonstrate ...

Brad G Hoffman et al.

BMC Developmental Biology , 08 Sep 2008

Identification of the bHLH Factor Math6 as a Novel Component of the Embryonic Pancreas Transcriptional Network: ... (Neurog3) controls endocrine cell fate specification in uncommitted progenitor cells. Therefore, it is likely that Neurog3-regulated factors will have important functions during pancreatic endocrine cell differentiation. The gene for the atonal -related bHLH factor Math6 was recognized as a potential target of Neurog3 in a genomic scale profiling during endocrine differentiation. Herein we have explored the role of Math6 during endocrine pancreas development. Results We ...

Francis C. Lynn et al.

PLoS ONE , 18 Jun 2008