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Etomidate definition: Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.
Etomidate definition: An imidazole derivative with short-acting sedative, hypnotic, and general anesthetic properties. Etomidate appears to have gamma-aminobutyric acid (GABA) like effects, mediated through GABA-A receptor. The action enhances the inhibitory effect of GABA on the central nervous system by causing chloride channel opening events which leads to membrane hyperpolarization.

Etomidate, sepsis, and adrenal function: not as bad as we thought?

Ryan Kamp et al.

Critical Care , 2007

Etomidate, pharmacological adrenalectomy and the critically ill: a matter of vital importance

Roxanna Bloomfield et al.

Critical Care , 2006

Effect of propofol and etomidate on normoxic and chronically hypoxic pulmonary artery

Nazinigouba Ouédraogo et al.

BMC Anesthesiology , 03 Mar 2006

The incidence of relative adrenal insufficiency in patients with septic shock after the administration of etomidate

Zulfiqar Mohammad et al.

Critical Care , 2006

Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shock: ... seriously ill patients, etomidate gives cardiovascular ...

David Charles Ray et al.

Critical Care , 2007

Mutational analysis of molecular requirements for the actions of general anaesthetics at the γ-aminobutyric acid A receptor subtype, α1β2γ2: ... actions of propofol, etomidate and enflurane, but not ...

Roberta Siegwart et al.

BMC Pharmacology , 12 Nov 2003

Mapping the contribution of β3-containing GABA A receptors to volatile and intravenous general anesthetic actions: ... immobilizing action of etomidate and propofol is ...

Anja Zeller et al.

BMC Pharmacology , 24 Feb 2007

New insight into the role of the β3 subunit of the GABA A -R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout: ... were less sensitive to etomidate. Forebrain selective ...

Carolyn Ferguson et al.

BMC Neuroscience , 10 Oct 2007

Impact of ε and θ subunits on pharmacological properties of α3β1 GABA A receptors expressed in Xenopus oocytes: ... modulatory effects by etomidate, propofol, pregnanolone ...

Martin Ranna et al.

BMC Pharmacology , 13 Jan 2006

Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics: ... metyrapone, R -etomidate, R -fadrazole and S ...

Luc Roumen et al.

Journal of Computer-Aided Molecular Design , 01 Aug 2007

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