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This preference, together with the strict requirement for a thymine base in position −1 for an efficient camptothecin binding, explains the temporary camptothecin resistance of the yeast cell expressing the mutant and points out the importance of the DNA sequence in the binding of the camptothecin drug.

Paola Fiorani et al.

Nucleic Acids Research 34 (18), 01 Oct 2006

We show here that a simple model of processes acting at the nucleotide level explains codon usage across a large sample of species (311 bacteria, 28 archaea and 257 eukaryotes).

Robin D Knight et al.

Genome Biology 2 (4), 2001

Position-dependent selection for error minimization explains why individual bases respond differently to directional mutation pressure.

Robin D Knight et al.

Genome Biology 2 (4), 2001

An amino acid's response (Figure 2a ) is determined by the mean GC content of its codons (that is, the amino acids with particularly AT- or GC-rich codons are most sensitive to genome GC content), which explains 71-79% of the variance in response, depending on the measure used (slope is the poorest fit; correlation coefficient is the best).

Robin D Knight et al.

Genome Biology 2 (4), 2001

The codon frequency in individual genes seems to be predictable on the basis of the overall GC content of the coding sequences: the relative GC content of individual codons explains about half the variance in response in their absolute frequencies within each coding sequence (that is, the presence or absence of a particular codon depends on the extent to which alternative synonyms of more 'suitable' GC content exist).

Robin D Knight et al.

Genome Biology 2 (4), 2001

275 further examples >>
Publications
 

The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant

Paola Fiorani et al.

Nucleic Acids Research , 01 Oct 2006

A simple model based on mutation and selection explains trends in codon and amino-acid usage and GC composition within and across genomes

Robin D Knight et al.

Genome Biology , 2001

Computational Model Explains High Activity and Rapid Cycling of Rho GTPases within Protein Complexes

Andrew B Goryachev et al.

PLoS Computational Biology , 01 Dec 2006

Modeling of Oxygen Transport and Cellular Energetics Explains Observations on In Vivo Cardiac Energy Metabolism

Daniel A Beard

PLoS Computational Biology , 01 Sep 2006

Entropy Explains Aging, Genetic Determinism Explains Longevity, and Undefined Terminology Explains Misunderstanding Both

Leonard Hayflick

PLoS Genetics , 01 Dec 2007

What explains between-school differences in rates of smoking?

Marion Henderson et al.

BMC Public Health , 20 Jun 2008

What explains between-school differences in rates of sexual experience?

Marion Henderson et al.

BMC Public Health , 08 Feb 2008

The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB

Elena Miranda et al.

Human Molecular Genetics , 01 Jun 2008

The sequence selectivity of KSRP explains its flexibility in the recognition of the RNA targets

María Flor García-Mayoral et al.

Nucleic Acids Research , 01 Sep 2008

Pathway Switching Explains the Sharp Response Characteristic of Hypoxia Response Network

Yihai Yu et al.

PLoS Computational Biology , 01 Aug 2007

270 further publications >>