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Transient transfection assay employing firefly luciferase as a reporter revealed that a ~1 kb sequence upstream of translational start site is sufficient for the functional transcriptional activity of falcipain -1 gene, while falcipain -2, -2' and -3 genes that exist within 12 kb stretch on chromosome 11 require ~2 kb upstream sequences for the expression of reporter luciferase activity.

Sujatha Sunil et al.

BMC Molecular Biology 9 (7), 14 May 2008

EMSA analysis elucidated binding of distinct nuclear factors to specific sequences within the 5'upstream regions of falcipain genes.

Sujatha Sunil et al.

BMC Molecular Biology 9 (7), 14 May 2008

However, we did find parasite specific sequence elements such as poly(dA) poly(dT) tracts, CCAAT boxes and a single 7 bp-G rich sequence, (A/G)NGGGG(C/A) in the 5' upstream regulatory regions of these genes, thereby suggesting the role(s) of Plasmodium specific transcriptional factors in the regulation of falcipain genes.

Sujatha Sunil et al.

BMC Molecular Biology 9 (7), 14 May 2008

Taken together, these results suggest that expression of Plasmodium cysteine proteases is regulated at the transcriptional level and parasite specific factors regulate the expression of falcipain genes.

Sujatha Sunil et al.

BMC Molecular Biology 9 (7), 14 May 2008

P. falciparum expresses four cysteine proteases namely, falcipain-1 (FP-1), falcipain-2 and -2' (FP-2A and FP-2B) and falcipain-3 (FP-3) at asexual blood stages of the parasite.

Sujatha Sunil et al.

BMC Molecular Biology 9 (7), 14 May 2008

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