dict.md logo
Choose languages of interest
SELECT >>
English
German
French
Italian
Portuguese
 
Add further languages:
Add all languages
Advertisement:
Definition
 
enEnglish
Abdomen, Acute definition: A clinical syndrome with acute abdominal pain that is severe, localized, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases.
Signs and Symptoms definition: Clinical manifestations that can be either objective when observed by a physician, or subjective when perceived by the patient.
sign/symptom definition: clinical manifestations that can be either objective when observed by a physician, or subjective when perceived by the patient.
Finding definition: Objective evidence of disease perceptible to the examining physician (sign) and subjective evidence of disease perceived by the patient (symptom).
Abdominal Abscess definition: An abscess located in the abdominal cavity, i.e., the cavity between the diaphragm above and the pelvis below. (From Dorland, 27th ed)
Finding definition: The result of an examination or inquiry.
Electrocardiographic Finding definition: Results of graphic tracing and measurements of the variations in electrical potential caused by the excitation of the heart muscle and detected at the body surface in relation to the diagnosis of coronary events compared with the absolute level of the measurement. The concept encompasses entirely normal, nonspecifically abnormal, and clearly abnormal findings.
Unrelated definition: Not connected or associated e.g. by kinship.
Married definition: A person currently joined in a legally binding matrimonial union. Classify common law marriage as married. Includes married couples living together and not living together.
MARRIED definition: A current marriage contract is active. (HL7)
19 further definitions >>
Examples
 

We used the chicken sequence to test comparative and homology-based gene-finding methods followed by experimental validation as an effective genome annotation method.

Eduardo Eyras et al.

BMC Bioinformatics 6 (7), 30 May 2005

We aimed to evaluate how de novo and homology-based gene finding methods perform in a newly sequenced genome for which a small number of gene sequences are known.

Eduardo Eyras et al.

BMC Bioinformatics 6 (7), 30 May 2005

International Chicken Genome Sequencing Consortium Sequence and Comparative Analysis of the Chicken Genome provide unique perspectives on vertebrate evolution Nature 2004 432 695 716 Erratum in: Nature 433(7027):777 15592404 10.1038/nature03154 Alexandersson MS Cawley Pachter L SLAM: cross-species gene finding and alignment with a generalized pair hidden Markov model Genome Res 2003 13 496 502 12618381 10.1101/gr.424203 Flicek PE Keibler P Hu I Korf Brent MR Leveraging the mouse genome for gene prediction in human: From whole-genome shotgun reads to a global synteny map Genome Res 2003 13 46 54 12529305 10.1101/gr.830003 Parra G Agarwal P Abril JF Wiehe T Fickett JW Guigo R Comparative Gene Prediction in Human and Mouse Genome Res 2003 13 108 117 12529313 10.1101/gr.871403 Tenney A Brown RH Vaske C Lodge JK Doering TL Brent MR Gene prediction and verification in a compact genome with numerous small introns Genome Res 2004 14 2330 2335 15479946 10.1101/gr.2816704 Wei C Lamesch P Arumugam M Rosenberg J Hu P Brent MR Vidal M Closing in on the C. elegans ORFeome by Cloning TWINSCAN Genome Res 2005 15 577 82 15805498 10.1101/gr.3329005 International Human Genome Sequencing Consortium Initial Sequencing and Analysis of the Human Genome Nature 2001 409 860 921 11237011 10.1038/35057062 Venter JC Adams MD Myers EW Li PW Mural RJ Sutton GG Smith HO Yandell M Evans CA Holt RA Gocayne JD Amanatides P Ballew RM Huson DH Wortman JR Zhang Q Kodira CD Zheng XH Chen L Skupski M Subramanian G Thomas PD Zhang J Gabor Miklos GL Nelson C Broder S Clark AG Nadeau J McKusick VA Zinder N Levine AJ Roberts RJ Simon M Slayman C Hunkapiller M Bolanos R Delcher A Dew I Fasulo D Flanigan M Florea L Halpern A Hannenhalli S Kravitz S Levy S Mobarry C Reinert K Remington K Abu-Threideh J Beasley E Biddick K Bonazzi V Brandon R Cargill M Chandramouliswaran I Charlab R Chaturvedi K Deng Z Di Francesco V Dunn P Eilbeck K Evangelista C Gabrielian AE Gan W Ge W Gong F Gu Z Guan P Heiman TJ Higgins ME Ji RR Ke Z Ketchum KA Lai Z Lei Y Li Z Li J Liang Y Lin X Lu F Merkulov GV Milshina N Moore HM Naik AK Narayan VA Neelam B Nusskern D Rusch DB Salzberg S Shao W Shue B Sun J Wang Z Wang A Wang X Wang J Wei M Wides R Xiao C Yan C Yao A Ye J Zhan M Zhang W Zhang H Zhao Q Zheng L Zhong F Zhong W Zhu S Zhao S Gilbert D Baumhueter S Spier G Carter C Cravchik A Woodage T Ali F An H Awe A Baldwin D Baden H Barnstead M Barrow I Beeson K Busam D Carver A Center A Cheng ML Curry L Danaher S Davenport L Desilets R Dietz S Dodson K Doup L Ferriera S Garg N Gluecksmann A Hart B Haynes J Haynes C Heiner C Hladun S Hostin D Houck J Howland T Ibegwam C Johnson J Kalush F Kline L Koduru S Love A Mann F May D McCawley S McIntosh T McMullen I Moy M Moy L Murphy B Nelson K Pfannkoch C Pratts E Puri V Qureshi H Reardon M Rodriguez R Rogers YH Romblad D Ruhfel B Scott R Sitter C Smallwood M Stewart E Strong R Suh E Thomas R Tint NN Tse S Vech C Wang G Wetter J Williams S Williams M Windsor S Winn-Deen E Wolfe K Zaveri J Zaveri K Abril JF Guigo R Campbell MJ Sjolander KV Karlak B Kejariwal A Mi H Lazareva B Hatton T Narechania A Diemer K Muruganujan A Guo N Sato S Bafna V Istrail S Lippert R Schwartz R Walenz B Yooseph S Allen D Basu A Baxendale J Blick L Caminha M Carnes-Stine J Caulk P Chiang YH Coyne M Dahlke C Mays A Dombroski M Donnelly M Ely D Esparham S Fosler C Gire H Glanowski S Glasser K Glodek A Gorokhov M Graham K Gropman B Harris M Heil J Henderson S Hoover J Jennings D Jordan C Jordan J Kasha J Kagan L Kraft C Levitsky A Lewis M Liu X Lopez J Ma D Majoros W McDaniel J Murphy S Newman M Nguyen T Nguyen N Nodell M Pan S Peck J Peterson M Rowe W Sanders R Scott J Simpson M Smith T Sprague A Stockwell T Turner R Venter E Wang M Wen M Wu D Wu M Xia A Zandieh A Zhu X The sequence of the human genome Science 2001 291 1304 51 Erratum in: Science 2001, 292(5523):1838 11181995 10.1126/science.1058040 Mouse Genome Sequence Consortium Initial sequencing and comparative analysis of the mouse genome Nature 2002 420 520 12466850 10.1038/nature01262 Rat Genome Sequencing Project Consortium Genome sequence of the Brown Norway rat yields insights into mammalian evolution Nature 2004 428 493 15057822 10.1038/nature02426 Aparicio S Chapman J Stupka E Putnam N Chia JM Dehal P Christoffels A Rash S Hoon S Smit A Gelpke MD Roach J Oh T Ho IY Wong M Detter C Verhoef F Predki P Tay A Lucas S Richardson P Smith SF Clark MS Edwards YJ Doggett N Zharkikh A Tavtigian SV Pruss D Barnstead M Evans C Baden H Powell J Glusman G Rowen L Hood L Tan YH Elgar G Hawkins T Venkatesh B Rokhsar D Brenner S Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes Science 2002 297 1301 10 12142439 10.1126/science.1072104 Boardman PE Sanz-Esquerro J Overton IM Burt DW Bosch E Fong WT Tickle C Brown WRA Wilson SA Hubbart SJ A comprehensive collection of chicken cDNAs Curr Biol 2002 12 1965 1969 12445392 10.1016/S0960-9822(02)01296-4 Curwen V Eyras E Andrews DT Clarke L Mongin E Searle S Clamp M The Ensembl Automatic Gene Annotation System Genome Res 2001 14 942 10.1101/gr.1858004 Korf I Flicek P Duan D Brent MR Integrating Genomic Homology into Gene Structure Prediction Bioinformatics 2001 17 140 148 Wu JQ Shteynberg D Arumugam M Gibbs RA Brent MR Identification of rat genes by TWINSCAN gene prediction, RT-PCR and direct sequencing Genome Res 2004 14 665 671 15060008 10.1101/gr.1959604 Guigo R Dermitzakis ET Agarwal P Ponting CP Parra G Reymond A Abril JF Keibler E Lyle R Ucla C Antonarakis SE Brent MR Comparison of mouse and human genomes followed by experimental verification yields an estimated 1,019 additional genes PNAS 2003 100 1140 1145 12552088 10.1073/pnas.0337561100 Makalowska I Sood R Faruque MU Hu P Robbins CM Eddings EM Mestre JD Baxevanis AD Carpten JD Identification of six novel genes by experimental validation of GeneMachine predicted genes Gene 2002 284 203 13 11891061 10.1016/S0378-1119(01)00897-6 Rogic S Ouellette BF Mackworth AK Improving gene recognition accuracy by combining predictions from two gene-finding programs Bioinformatics 2002 18 1034 45 12176826 10.1093/bioinformatics/18.8.1034 Howe KL Chothia T Durbin R GAZE: a generic framework for the integration of gene-prediction data by dynamic programming Genome Res 2002 12 1418 27 12213779 10.1101/gr.149502 Zhang L Pavlovic V Cantor CR Kasif S Human-Mouse Gene Identification by Comparative Evidence Integration and Evolutionary Analysis Genome Res 2003 13 1190 1202 12743024 10.1101/gr.703903 Yada T Totoki Y Takaeda Y Sakaki Y Takagi T DIGIT: A Novel Gene Finding Program by Combining Gene-Finders Proceedings of the 8th Pacific Symposium on Biocomputing (PSB 2003), Lihue, Hawaii, USA 375 387 January 3–7, 2003 Allen JE Pertea M Salzberg SL Computational gene prediction using multiple sources of evidence Genome Res 2004 14 142 8 14707176 10.1101/gr.1562804 Das M Burge CB Park E Colinas J Pelletier J Assessment of the total number of human transcription units Genomics 2001 77 71 8 11543635 10.1006/geno.2001.6620 Eyras E Caccamo M Curwen V Clamp M ESTgenes: Alternative splicing from ESTs in Ensembl Genome Res 2004 14 976 15123595 10.1101/gr.1862204 Hubbard SJ Graham DV Beattie KJ Overton IA McLaren SR Croning MDR Boardman PE Bonfield JK Burnside J Davies RM Farrel ER Francis MD Griffiths-Jones S Humphray SJ Hyland C Scott CE Tang H Taylor RG Tickle C Brown WRA Birney E Rogers J Wilson SA Transcriptome Analysis for the Chicken Based on 19,626 Finished cDNA Sequences and 485,337 Expressed Sequence Tags Genome Res 2005 15 174 83 15590942 10.1101/gr.3011405 Pruitt KD Maglott DR RefSeq and LocusLink: NCBI gene-centered resources Nucleic Acids Res 2001 29 137 140 11125071 10.1093/nar/29.1.137 Altschul SF Gish W Miller W Myers EW Lipman DJ Basic local alignment search tool J Mol Biol 1990 215 403 410 2231712 10.1006/jmbi.1990.9999 Slater GS Birney E Automated generation of heuristics for biological sequence comparison BMC Bioinformatics 2005 6 31 15713233 10.1186/1471-2105-6-31 Dermitzakis ET Reymond A Lyle R Scamuffa N Ucla C Deutsch S Stevenson BJ Flegel V Bucher P Jongeneel CV Antonarakis SE Numerous potentially functional but non-genic conserved sequences on human chromosome 21 Nature 2002 420 578 82 12466853 10.1038/nature01251 Dermitzakis ET Reymond A Scamuffa N Ucla C Kirkness E Rossier C Antonarakis SE Evolutionary discrimination of mammalian conserved non-genic sequences (CNGs) Science 2003 302 1033 5 14526086 10.1126/science.1087047 Reymond A Camargo AA Deutsch S Stevenson BJ Parmigiani RB Ucla C Bettoni F Rossier C Lyle R Guipponi M de Souza S Iseli C Jongeneel CV Bucher P Simpson AJ Antonarakis SE Nineteen additional unpredicted transcripts from human chromosome 21 Genomics 2002 79 824 32 12036297 10.1006/geno.2002.6781 Scripts to generate intron assemblies from prediction sets: Download page for SGP2 software and predictions: Download page for TWINSCAN software and predictions: Website for Ensembl predictions in chicken: Website with supplementary data: Figures and Tables Figure 1 Venn diagram of the prediction sets.

Eduardo Eyras et al.

BMC Bioinformatics 6 (7), 30 May 2005

Recent advances in genome sequence availability and in high-throughput gene expression analysis technologies have allowed for the development of computational methods for motif finding.

Modan K Das et al.

BMC Bioinformatics 8 (Suppl 7), 01 Nov 2007

As a result, a large number of motif finding algorithms have been implemented and applied to various motif models over the past decade.

Modan K Das et al.

BMC Bioinformatics 8 (Suppl 7), 01 Nov 2007

2427 further examples >>
Publications
 

Gene finding in the chicken genome

Eduardo Eyras et al.

BMC Bioinformatics , 30 May 2005

Finding Groups in Gene Expression Data

David J. Hand et al.

Journal of Biomedicine and Biotechnology , 2005

A survey of DNA motif finding algorithms

Modan K Das et al.

BMC Bioinformatics , 01 Nov 2007

GeneMark.hmm: new solutions for gene finding.

A V Lukashin et al.

Nucleic Acids Research , 15 Feb 1998

Finding disease candidate genes by liquid association

Ker-Chau Li et al.

Genome Biology , 2007

An efficient method for finding repeats in molecular sequences.

H M Martinez

Nucleic Acids Research , 11 Jul 1983

Dictionary-driven prokaryotic gene finding

Tetsuo Shibuya et al.

Nucleic Acids Research , 15 Jun 2002

A combinatorial optimization approach for diverse motif finding applications

Elena Zaslavsky et al.

Algorithms for Molecular Biology , 17 Aug 2006

Algorithms for Finding Small Attractors in Boolean Networks

Shu-Qin Zhang et al.

EURASIP Journal on Bioinformatics and Systems Biology , 2007

BioCreAtIvE Task 1A: gene mention finding evaluation

Alexander Yeh et al.

BMC Bioinformatics , 24 May 2005

2422 further publications >>