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Translation
 
enEnglish deGerman
1 word
hypothetical hypothetisch
hypothetical hypothetische
 
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enEnglish eoEsperanto
1 word
hypothetical supozita
 
enEnglish frFrench
1 word
hypothetical hypothétique
 
enEnglish ioIdo
1 word
hypothetical hipotezala
 
enEnglish nlDutch
1 word
hypothetical hypothetisch
hypothetical vermeend
hypothetical verondersteld
 
enEnglish ptPortuguese
1 word
hypothetical suposto
 
enEnglish ruRussian
1 word
hypothetical гадательный
 
Definition
 
enEnglish
Interleukin-14 definition: Interleukin-14, encoded by the IL14 gene, is a cytokine that induces B-cell proliferation, inhibits immunoglobulin secretion, and selectively expands certain B-cell subpopulations.
Apoptosis Response Protein definition: Apoptosis Response Protein, encoded by the PAWR gene, is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. Apoptosis Response Protein is specifically upregulated during apoptosis of prostate cells. (from LocusLink)
DNA Topoisomerase II Binding Protein definition: Topoisomerase (DNA) II Binding Protein (TOPBP1), encoded by the TopBP1 gene, is a 173-kD binding protein that interacts with the C-terminal region of topoisomerase II beta. TOPBP1 may stimulate catalytic activity of topoisomerase II beta through transient breakages of DNA strands. (From LocusLink)
D5S346 definition: A dinucleotide repeat on chromosome 5 that serves as a marker for microsatellite instability in colorectal cancers.
Epidermal Growth Factor Receptor Pathway Substrate 8-Like Protein 2 definition: Encoded by human EPS8L2 Gene, EPS8-Related Protein 2 is a protein of unknown function related to EGFR Pathway Substrate 8 (EPS8), a substrate for the EGFR. (NCI)
SID1 Transmembrane Family, Member 1 definition: Encoded by human FLJ20174 Gene, Hypothetical Protein FLJ20174 is a potential homolog of sid-1 (C. elegans), a predicted transmembrane protein localized to the cell periphery, and required cell autonomously for systemic RNA interference (RNAi). (NCI)
Serologically Defined Breast Cancer Antigen 84 definition: Encoded by human NY-BR-84 Gene, the widely expressed 383-amino acid 43 kD NY-BR-84 Protein has an unknown function and sequence similarity to acyl-CoA thioesterase (C. elegans) and serologically defined breast cancer antigen 84 (Mouse). (from SWISS-PROT, LocusLink, and NCI)
TOPBP1 wt Allele definition: Human TOPBP1 wild-type allele is located in the vicinity of 3q22.1 and is approximately 61 kb in length. This allele, which encodes DNA topoisomerase 2-binding protein 1, is involved in DNA double-strand breaks, and map play a role in DNA damage and replication checkpoint controls.
 
deGerman
hypothetisch definition: [1] in Art einer Hypothese; auf einer ungesicherten Grundlage [2] eine Hypothese betreffend
 
Examples
 

Tel: +1 301 435 5913; Fax: +1 301 435 7794; Email: [email protected] 2004 12 10 2004 32 18 5452 5463 18 8 2004 22 9 2004 22 9 2004 Copyright © 2004 Oxford University Press 2004 Comparative genomics shows that a substantial fraction of the genes in sequenced genomes encodes ‘conserved hypothetical’ proteins, i.e. those that are found in organisms from several phylogenetic lineages but have not been functionally characterized.

Michael Y. Galperin et al.

Nucleic Acids Research 32 (18), 2004

Here, we briefly discuss recent progress in functional characterization of prokaryotic ‘conserved hypothetical’ proteins and the possible criteria for prioritizing targets for experimental study.

Michael Y. Galperin et al.

Nucleic Acids Research 32 (18), 2004

The experimental characterization of these and other ‘conserved hypothetical’ proteins is expected to reveal new, crucial aspects of microbial biology and could also lead to better functional prediction for medically relevant human homologs.

Michael Y. Galperin et al.

Nucleic Acids Research 32 (18), 2004

Remarkably, species- or genus-specific genes comprise a relatively small fraction of the uncharacterized genes; the majority of such ‘hypothetical’ genes have a wider phyletic distribution and therefore are usually referred to as ‘conserved hypothetical’ ( 9 , 10 ).

Michael Y. Galperin et al.

Nucleic Acids Research 32 (18), 2004

Although species-specific ‘ORFans’ should not be neglected ( 11 – 14 ), ‘conserved hypothetical’ proteins pose a challenge not just to functional genomics, but also to biology in general ( 9 ).

Michael Y. Galperin et al.

Nucleic Acids Research 32 (18), 2004

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