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Definition
 
enEnglish
Largest definition: Greatest in size of those under consideration.
DNA Directed RNA Polymerase II Polypeptide A definition: Encoded by human POLR2A Gene (RNA Polymerase Beta Prime Chain Family), nuclear 1970-aa 220-kD DNA Directed RNA Polymerase II Polypeptide A is the largest of 12 subunits of RNA polymerase II that catalyzes transcription of DNA in eukaryotes into mRNA precursor. The C-terminal domain (CTD) heptapeptide repeats contain highly phosphorylated activating serine and threonine residues. POLR2A and other subunits form the polymerase DNA binding domain, where the DNA template is transcribed. POLR2A couples transcription with pre-mRNA processing. The hyperphosphorylated CTD interacts with FNBP3 and recruits factors for mRNA capping, splicing, and 3'-processing. POLR2A interacts with SAFB/SAFB1. POLR2A is ubiquitinated after damage of genes repaired by transcription-coupled repair.
 
deGerman
flächengroß definition: [1] besonders groß, eine besonders große Fläche aufweisend
 
Publications
 

Structure and sequence of the gene for the largest subunit of trypanosomal RNA polymerase III.

J Köck et al.

Nucleic Acids Research , 26 Sep 1988

Analysis of the largest tandemly repeated DNA families in the human genome

Peter E Warburton et al.

BMC Genomics , 07 Nov 2008

In vivo degradation of RNA polymerase II largest subunit triggered by alpha-amanitin.

V T Nguyen et al.

Nucleic Acids Research , 01 Aug 1996

Cloning and sequence determination of the Schizosaccharomyces pombe rpb1 gene encoding the largest subunit of RNA polymerase II.

Y Azuma et al.

Nucleic Acids Research , 11 Feb 1991

An enlarged largest subunit of Plasmodium falciparum RNA polymerase II defines conserved and variable RNA polymerase domains.

W B Li et al.

Nucleic Acids Research , 11 Dec 1989

The nuclear matrix protein p255 is a highly phosphorylated form of RNA polymerase II largest subunit which associates with spliceosomes.

M Vincent et al.

Nucleic Acids Research , 01 Dec 1996

Unusual C-terminal domain of the largest subunit of RNA polymerase II of Crithidia fasciculata.

R Evers et al.

Nucleic Acids Research , 11 May 1989

The Trypanosoma brucei protein phosphatase gene: polycistronic transcription with the RNA polymerase II largest subunit gene.

R Evers et al.

Nucleic Acids Research , 11 Sep 1990

African swine fever virus encodes two genes which share significant homology with the two largest subunits of DNA-dependent RNA polymerases.

R J Yáñez et al.

Nucleic Acids Research , 25 May 1993

Similar upstream regulatory elements of genes that encode the two largest subunits of RNA polymerase II in Saccharomyces cerevisiae.

D B Jansma et al.

Nucleic Acids Research , 15 Nov 1996

989 further publications >>