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Arachidonate 5-Lipoxygenase definition: An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes. EC 1.13.11.34.
Arachidonate 5-Lipoxygenase definition: Arachidonate 5-lipoxygenase protein (674 aa, ~78 kDa) is encoded by the human ALOX5 gene. This protein plays a role in the synthesis of leukotrienes from arachidonic acid; thus, it mediates both inflammation and allergen responses.
Leukotriene C4 definition: The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Leukotriene D4 definition: One of the biologically active principles of SRS-A. It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage of the gamma-glutamyl portion. Its biological actions include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Leukotrienes definition: A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.
leukotriene definition: family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway; participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation; have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.
Leukotriene B4 definition: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
Leukotriene A4 definition: (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Leukotriene E4 definition: A biologically active principle of SRS-A that is formed from LEUKOTRIENE D4 via a peptidase reaction that removes the glycine residue. The biological actions of LTE4 are similar to LTC4 and LTD4. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Receptors, Leukotriene definition: Cell-surface receptors that bind LEUKOTRIENES with high affinity and trigger intracellular changes influencing the behavior of cells. The leukotriene receptor subtypes have been tentatively named according to their affinities for the endogenous leukotrienes LTB4; LTC4; LTD4; and LTE4.
5 further definitions >>
Publications
 

Interleukin-5 Potentiates Sulfidopeptide Leukotriene Production by Human Eosinophils

A. J. M. Van Oosterhout et al.

Mediators of Inflammation , 1994

Influence of leukotriene gene polymorphisms on chronic rhinosinusitis

Hasan Al-Shemari et al.

BMC Medical Genetics , 26 Mar 2008

Leukotriene inhibition in hamster periodontitis. A histochemical and morphometric study

B. Baroukh et al.

Mediators of Inflammation , 1992

PPAR α / γ -Independent Effects of PPAR α / γ Ligands on Cysteinyl Leukotriene Production in Mast Cells

Masamichi Yamashita

PPAR Research , 2008

Leukotriene C 4 biosynthesis in isolated August rat peritoneal leukocytes

J. M. Huebner et al.

Mediators of Inflammation , 01 Dec 1996

Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice

Laura McKinley et al.

Respiratory Research , 2006

The effect of inhibition of leukotriene synthesis on the activity of interleukin-8 and granulocyte-macrophage colony-stimulating factor

P. J. Roberts et al.

Mediators of Inflammation , 1993

The Role of PPAR γ Receptors and Leukotriene B 4 Receptors in Mediating the Effects of LY293111 in Pancreatic Cancer

Thomas E. Adrian et al.

PPAR Research , 2008

Leukotriene B 4 -loaded microspheres: a new therapeutic strategy to modulate cell activation

Roberto Nicolete et al.

BMC Immunology , 15 Jul 2008

Inhibitory effect of LY 255283 on the synthesis of leukotriene B 4 and thromboxane A 2 in human peripheral blood polymorphonuclear leukocytes and monocytes

M. Uğur et al.

Mediators of Inflammation , 1993

81 further publications >>