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Intercalating Agents definition: Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.
Ligands definition: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
ligand definition: molecule that binds to another molecule, especially a small molecule that binds specifically to a larger molecule.
Tumor Necrosis Factors definition: A family of proteins that were originally identified by their ability to cause NECROSIS of NEOPLASMS. Their necrotic effect on cells is mediated through TUMOR NECROSIS FACTOR RECEPTORS which induce APOPTOSIS.
Tumor Necrosis Factor Family Protein definition: Family of cell surface proteins structurally related to tumor necrosis factor. They are involved in lymphocyte homeostasis by their ability to induce apoptosis.
Tumor Necrosis Factor Family Protein definition: (TOO-mer ne-KRO-sis) A type of biological response modifier that can improve the body's natural response to disease. (NCI-GLOSS)
early endosome definition: Small irregularly shaped intracellular vesicles to which endocytosed molecules are initially delivered. [GOC:rb]
endocytotic transport vesicle definition: OBSOLETE (was not defined before being made obsolete). [GOC:go_curators]
endocytic vesicle definition: A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. [GOC:go_curators]
Ephrins definition: Signaling proteins that are ligands for the EPH FAMILY RECEPTORS. They are membrane-bound proteins that are attached to the CELL MEMBRANE either through a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR or through a transmembrane domain. Many of the ephrins are considered important intercellular signaling molecules that control morphogenic changes during embryogenesis.
4 further definitions >>
Publications
 

PPAR Ligands for Cancer Chemoprevention

Yumiko Yasui et al.

PPAR Research , 2008

Therapeutic androgen receptor ligands

George F. Allan et al.

Nuclear Receptor Signaling , 27 Sep 2003

The B7 family of immune-regulatory ligands

Mary Collins et al.

Genome Biology , 2005

Structural insights into regulation of nuclear receptors by ligands

Eric H. Xu et al.

Nuclear Receptor Signaling , 15 Jun 2003

Pharmacological profiles of opioid ligands at Kappa opioid receptors

Parham Gharagozlou et al.

BMC Pharmacology , 25 Jan 2006

Clinical Use of PPAR γ Ligands in Cancer

Jennifer L. Hatton et al.

PPAR Research , 2008

kinDOCK: a tool for comparative docking of protein kinase ligands

Laetitia Martin et al.

Nucleic Acids Research , 01 Jul 2006

PPAR Ligands as Potential Modifiers of Breast Carcinoma Outcomes

Ancha Baranova

PPAR Research , 2008

PPAR α Ligands as Antitumorigenic and Antiangiogenic Agents

Ambra Pozzi et al.

PPAR Research , 2008

High-affinity RNA ligands to human alpha-thrombin.

M F Kubik et al.

Nucleic Acids Research , 11 Jul 1994

957 further publications >>