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Recent data suggest that mepolizumab, an anti-IL-5 antibody, is an effective corticosteroid-sparing agent for F/P-negative patients.

Florence E Roufosse et al.

Orphanet Journal of Rare Diseases 2 (7), 11 Sep 2007

Initially, two molecules were developed for intravenous use (mepolizumab by GlaxoSmithKline and formerly SCH55700 by Schering Plough) and tested in HES patients, some of whom were corticosteroid non-responders, in the setting of compassionate use programs.

Florence E Roufosse et al.

Orphanet Journal of Rare Diseases 2 (7), 11 Sep 2007

Among patients under corticosteroids before treatment initiation, several could be tapered down or off after mepolizumab infusions, supporting its use as a corticosteroid-sparing agent in HES.

Florence E Roufosse et al.

Orphanet Journal of Rare Diseases 2 (7), 11 Sep 2007

Eosinophil depletion and clinical remission following administration of 750 mg mepolizumab appears to last weeks or even months in some cases, and two patients with eosinophilic dermatitis have experienced persistent remission (with follow-up of 17 months in one case) following treatment discontinuation [ 47 ].

Florence E Roufosse et al.

Orphanet Journal of Rare Diseases 2 (7), 11 Sep 2007

Although SCH55700 is no longer available, mepolizumab has recently been administered to a large number of F/P-negative corticosteroid-responsive HES patients in the setting of an international multicentric, randomized, double-blind, placebo-controlled clinical trial (750 mg administered intravenously every 4 weeks) [ 50 ].

Florence E Roufosse et al.

Orphanet Journal of Rare Diseases 2 (7), 11 Sep 2007

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Hypereosinophilic syndromes: ... data suggest that mepolizumab, an anti-IL-5 antibody, ...

Florence E Roufosse et al.

Orphanet Journal of Rare Diseases , 11 Sep 2007