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Definition
 
enEnglish
Antimutagenic Agents definition: Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.
error-prone DNA repair definition: DNA repair pathways that tend to increase the endogenous mutation rate. [GOC:jl, PMID:11459974]
error-prone postreplication DNA repair definition: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication, without removing the replication-blocking lesions, and with an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. [GOC:jl, PMID:11485998]
Pathologic Mutagenesis definition: Any event, process, or activity that produces a deleterious alteration of DNA. (NCI)
 
Examples
 

Data on raw water quality, disinfection treatment practices, and the resulting mutagenic properties of the treated water were compiled from pilot- and full-scale treatment experiments to evaluate that parameter which might produce variability in the results of a mutagenic study.

L Cognet et al.

Environmental Health Perspectives 69 (7), 01 Nov 1986

Analysis of the data and comparison of treatment practices indicated that the measured mutagenic activity is strongly related to the characteristics of the organic matter in the raw water, the methodology used to sample and detect mutagens, the scale of the study both in terms of treatment flow and period of study, and the point at which and the conditions under which oxidants are added during treatment.

L Cognet et al.

Environmental Health Perspectives 69 (7), 01 Nov 1986

Conclusions regarding disinfection systems in full-scale water treatment plants include the following: When raw water is pretreated and high concentrations of organics are present in the raw water, both ozonation and chlorination increased mutagenic activity.

L Cognet et al.

Environmental Health Perspectives 69 (7), 01 Nov 1986

Both in the case of a nitrified groundwater and a clarified surface water, the mutagenic activity of the water after ozonation was related to its mutagenic activity before ozonation.

L Cognet et al.

Environmental Health Perspectives 69 (7), 01 Nov 1986

With ozonation, mutagenic activity decreased after granular activated carbon (GAC) filtration.

L Cognet et al.

Environmental Health Perspectives 69 (7), 01 Nov 1986

512 further examples >>
Publications
 

Mutagenic activity of disinfection by-products.

L Cognet et al.

Environmental Health Perspectives , 01 Nov 1986

Carcinogenic, teratogenic, and mutagenic effects of arsenic.

V Bencko

Environmental Health Perspectives , 01 Aug 1977

Mutagenic/carcinogenic potential of DEHP and MEHP.

I Tomita et al.

Environmental Health Perspectives , 01 Nov 1982

Distinction of mutagenic carcinogens from a mutagenic noncarcinogen in the big blue transgenic mouse.

M L Cunningham et al.

Environmental Health Perspectives , 01 May 1996

Detection of mutagenic activity in the urines of anesthesiologists: a preliminary report.

E C McCoy et al.

Environmental Health Perspectives , 01 Dec 1977

Antimutagenic and mutagenic potentials of Chinese radish.

W Rojanapo et al.

Environmental Health Perspectives , 01 Oct 1993

N-hydroxylation of carcinogenic and mutagenic aromatic amines.

R Kato et al.

Environmental Health Perspectives , 01 Mar 1983

Mutagenic activity of phthalate esters in bacterial liquid suspension assays.

J L Seed

Environmental Health Perspectives , 01 Nov 1982

Organic emissions from coal pyrolysis: mutagenic effects.

A G Braun et al.

Environmental Health Perspectives , 01 Aug 1987

Template properties of mutagenic cytosine analogues in reverse transcription

Tetsuya Suzuki et al.

Nucleic Acids Research , 01 Dec 2006

507 further publications >>