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Translation
 
enEnglish deGerman
1 word
necessary benötigend
necessary dazugehörig
necessary erfordelich
necessary erforderlich
necessary not
necessary notwendig
necessary nötig
necessary verpflichtet
necessary vonnöten
necessary wichtig
37 further results >>
 
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enEnglish itItalian
1 word
necessary necessario
necessary occorrente
2 words
absolutely necessary assolutamente necessario
absolutely necessary indispensabile
if necessary accessoriamente
 
enEnglish caCatalan
1 word
necessary necessari
2 words
if necessary accessòriament
 
enEnglish esSpanish
1 word
necessary exigido
necessary imprescindible
necessary juego
necessary necesario
necessary obligatorio
necessary requisito
2 words
if necessary accesoriamente
 
enEnglish frFrench
1 word
necessary exigé
necessary indispensable
necessary jeu
necessary mobilisé
necessary nécessaire
necessary nécessairement
necessary obligatoire
necessary requis
necessary réquisitionné
2 words
if necessary accessoirement
1 further results >>
 
enEnglish afAfrikaans
1 word
necessary benodig
necessary nodig
 
enEnglish csCzech
1 word
necessary třeba
necessary zapotřebí
 
enEnglish daDanish
1 word
necessary fornødne
 
enEnglish eoEsperanto
1 word
necessary bezona
necessary bezonega
necessary necesa
 
enEnglish fiFinnish
1 word
necessary tarpeellinen
necessary välttämätön
 
enEnglish huHungarian
1 word
necessary megkívánható
necessary megkívánt
necessary szükséges
 
enEnglish ioIdo
1 word
necessary necesa
 
enEnglish nlDutch
1 word
necessary benodigd
necessary nodig
necessary van node
 
enEnglish ocOccitan (post 1500); Provençal
1 word
necessary necessari
 
enEnglish plPolish
1 word
necessary konieczny
necessary potrzebny
 
enEnglish ptPortuguese
1 word
necessary necessário
necessary preciso
 
enEnglish ruRussian
1 word
necessary необходимо
necessary необходимый|необходимым
 
enEnglish skSlovak
1 word
necessary naliehavý
necessary súrny
necessary treba
 
enEnglish srSerbian
1 word
necessary neophodan
 
enEnglish trTurkish
1 word
necessary gerekli
necessary lazım
necessary zorunlu
 
Definition
 
enEnglish
Extracellular Matrix Binding Pathway definition: Activation of the MAPK kinase pathway has been identified as a mechanism that integrins use to regulate gene expression, leading to cell shape changes during cell spreading or migration. Epithelial cells respond to extracellular matrix (ECM) causing integrin-mediated FAK phosphorylation; this, in turn, phosphorylates the surrounding proteins (paxillin, Fyn/shc, and src) and leads to signal amplification. FAK also binds PI-3 kinase and acts upstream in the MAP kinase pathway. When MAP kinase or PI-3 kinase is inhibited, actin reorganization is blocked. Src phosphorylates p190RhoGAP, inactivating its GAP function and allowing RhoGTP to stay active longer, promoting further signal amplification. Activated RhoGTP binds to downstream kinases such as Rho-associated coiled coil-containing protein kinase (p160ROCK) and p140 diaphanous (p140Dia) to increase actin polymerization and contraction. Actin reorganization assists integrin clustering, allowing more ECM binding that increase FAK phosphorylation and other signal transduction events. (Biocarta)
PRN definition: As needed. (NCI)
As Necessary definition: As needed, usually referring to the timing of the administration of a treatment or medication.
necessary definition: [1] erforderlich, notwendig, nötig haben
 
deGerman
notwendig definition: [1] unter allen Umständen erforderlich [2] in der Konsequenz unvermeidbar
nötig definition: [1] dringend erforderlich, nicht entbehrlich
unumgänglich definition: [1] nicht zu umgehen, unausweichlich, absolut notwendig, absolut erforderlich
vonnöten definition: [1] für einen bestimmten Zweck zwingend, nachdrücklich geboten, nötig
erforderlich definition: [1] jemand/etwas ist nötig, wird gebraucht
not definition: [1] selten, veraltend: notwendig, nötig
 
frFrench
requis definition: Personne contrainte à effectuer une tâche par les autorités lors d’une guerre.
 
Publications
 

Is fasting a necessary preparation for abdominal ultrasound?

Tariq Sinan et al.

BMC Medical Imaging , 22 Jul 2003

Clade, Country and Region-specific HIV-1 Vaccines: Are they necessary?

Karen S Slobod et al.

AIDS Research and Therapy , 28 Apr 2005

Phosphorylation of the Arp2/3 complex is necessary to nucleate actin filaments

Lawrence L. LeClaire et al.

The Journal of Cell Biology , 25 Aug 2008

An immune reaction may be necessary for cancer development

Richmond T Prehn

Theoretical Biology & Medical Modelling , 03 Feb 2006

Visual Feedback Is Not Necessary for the Learning of Novel Dynamics

David W. Franklin et al.

PLoS ONE , 19 Dec 2007

The necessary length of carbon nanotubes required to optimize solar cells

Majid Vaezzadeh et al.

Chemistry Central Journal , 01 Oct 2007

Six novel genes necessary for pre-mRNA splicing in Saccharomyces cerevisiae.

J R Maddock et al.

Nucleic Acids Research , 15 Mar 1996

Regulatory regions of rat insulin I gene necessary for expression in transgenic mice.

F Dandoy-Dron et al.

Nucleic Acids Research , 25 Sep 1991

Modulating Vesicle Priming Reveals that Vesicle Immobilization Is Necessary but not Sufficient for Fusion-Competence

Ofer Yizhar et al.

PLoS ONE , 16 Jul 2008

Cauda equina compression in an achondroplastic dwarf. Is complex anterior and posterior surgical intervention necessary?

George Sapkas et al.

Scoliosis , 04 Dec 2008

3186 further publications >>