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Cell Adhesion Molecules, Neuronal definition: Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
Synaptic Transmission definition: The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.
neural transmission definition: communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
transmission of nerve impulse definition: The sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation. [http://cancerweb.ncl.ac.uk]
synaptic transmission definition: The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. [GOC:jl, MeSH:D009435]
Neuronal Transmission definition: Neuronal Transmission is the intercellular propagation or transfer of a signal, from a neuron to a recipient cell, consisting of an electrical current by ion flux via gap junction or diffusion a chemical neurotransmitter across a synaptic or neuromuscular junction.
neuronal ceroid lipofuscinosis definition: inherited degenerative disease characterized by neuronal cytoplasmic inclusions which stain positively for ceroid and lipofuscin.
Neuronal Ceroid-Lipofuscinoses definition: A group of severe neurodegenerative diseases characterized by intracellular accumulation of autofluorescent wax-like lipid materials (CEROID; LIPOFUSCIN) in neurons. There are several subtypes based on mutations of the various genes, time of disease onset, and severity of the neurological defects such as progressive DEMENTIA; SEIZURES; and visual failure.
neuronal ceroid lipofuscinosis (CLN) definition: A group of inherited progressive neurometabolic diseases, previously considered as several separate syndromic entities, with considerable variability in clinical, pathological manifestations, and genetic findings. All diseases in this groups are characterized by abnormal storage of the autofluorescent proteolipopigments in neuronal and other structures with an average incidence estimated at 1:5/100,000. Six principal types are classified on the basis of age of onset, clinical manifestations, pathological changes, and genetic features. There appears to be a lack of uniformity in classification of CLN-5 and CLN-6. CLN-5 Boehme disease) is listed in OMIM in the Autosomal Dominant Catalog (OMIM: 162350) without a CLN number, and the late infantile variant as CLN- 5 (OMIM: 256731). CLN-7 has been added to include atypical forms of neuronal ceroid-lipofuscinosis that have not been included in previous classifications. Neuronal ceroid-lipofuscinosis type 1 (CLN-1) Synonyms: Hagberg-Santavuori disease Haltia-Santavuori disease Santavuori disease Santavuori-Haltia disease acute infantile neuronal ceroid-lipofuscinosis infantile Finnish type of neuronal ceroid-lipofuscinosis infantile neuronal ceroid-lipofuscinosis (INCL) polyunsaturated fatty acid lipidosis A variant encountered most frequently in Finland, hence the synonym infantile Finnish type of neuronal ceroid-lipofuscinosis, with onset at age 6 to 18 months and a subacute course. It is characterized by rapid deterioration with psychomotor retardation, loss of speech, seizures, ataxia, blindness, hypotonia, microcephaly, and occasional convulsions. Mapped to chromosome 1p32. The gene is known to be the palmityl-protein trioesterase. Transmitted as an autosomal recessive trait. (OMIM 256730) Neuronal ceroid-lipofuscinosis type 2 (CLN-2) Synonyms: Bernheimer-Seitelberger syndrome Bielschowsky amaurotic idiocy Bielschowsky disease Jansky-Bielschowsky disease Seitelberger disease late infantile amaurotic idiocy late infantile Batten disease late infantile neuronal lipofuscinosis (LINCL) subacute late infantile neuronal ceroid- lipofuscinosis The second most common variant with a subacute course after onset in infancy or early childhood characterized by refractive epilepsy, mental regression, ataxia, visual loss, and progressive deterioration. Mapped to chromosome 11p15. Pepstatin insensitive carboxypeptidase, 46dKa protein, Cys365->Tyr, Arg 208>umber stop codon, AG or intronic 3'spine junction to AC are the genetic features. Transmitted as an autosomal recessive trait. (OMIM 294500) neuronal ceroid-lipofuscinosis type 3 (CLN-3) Synonyms: Batten syndrome (BTS) Batten-Mayou syndrome Batten-Spielmeyer-Vogt disease Spielmeyer-Sjogren syndrome Spielmeyer-Vogt-Batten disease Spielmeyer-Vogt-Sjogren disease Stock-Spielmeyer-Vogt syndrome Vogt-Spielmeyer disease chronic juvenile neuronal ceroid-lipofuscinosis (JNCL) juvenile amaurotic family idiocy juvenile amaurotic idiocy juvenile Batten disease juvenile cerebrorenal degeneration juvenile neuronal lipofuscinosis (JNCL) juvenile onset neuronal ceroid-lipofuscinosis pigmentary retinal neuronal heredodegeneration The most commonly occurring variant with a chronic course after juvenile onset with an estimated incidence of 1:25,000. The first symptom is usually visual failure which takes place between the ages of 4 and 15 years. The early symptoms are followed by epilepsy and progressive physical and mental deterioration. Batten disease gene maps to chromosome 16p12.1. 56 chromosome haplotype defined by alleles at the D16S299 is shared by 73% of Batten disease chromosomes. Exon amplification of a cosmid containing D16S298 has yielded a candidate gene that is disrupted by kb genomic deletion in patients with 56 chromosomes. The disease gene encodes a 436 amino acid protein of unknown function. Transmitted as an autosomal recessive trait. (OMIM 294200) neuronal ceroid-lipofuscinosis type 4 (CLN-4) Synonyms: Kufs disease Kufs-Mayer disease adult amaurotic idiocy adult ceroid lipofuscinosis adult ganglioside lipidosis adult neuronal ceroid-lipofuscinosis adult recessive neuronal ceroid lipofuscinosis chronic adult-recessive neuronal ceroid-lipofuscinosis late familial amaurotic idiocy late ganglioside lipidosis A rare variant with onset of symptoms between the ages of 20 and 50 years with a chronic course and associated with cerebellar ataxia, bulbar symptoms, and extrapyramidal and pyramidal signs, but without retinal lesions and rapidly progressive dementia. Transmitted as an autosomal recessive trait but some cases are sporadic. (OMIM 204300) neuronal ceroid-lipofuscinosis type 5 (CLN-5) Synonyms: Boehme disease Parry neuronal ceroid-lipofuscinosis adult dominant neuronal ceroid-lipofuscinosis chronic adult dominant neuronal ceroid-lipofuscinosis dominant Kufs disease dominant neuronal ceroid-lipofuscinosis A cerebellar syndrome with onset early in fourth decade, characterized by epileptic fits, myoclonic epilepsy, progressive dementia, and hypertension. 11 cases were reported in four generations of a family named Parry. Transmitted as an autosomal dominant trait. (OMIM 162350) neuronal ceroid-lipofuscinosis type 6 (CLN-6) Synonyms: Zeman-Dyken-Lake-Santavuori-Savukoski disease subacute transitional early juvenile neuronal ceroid-lipofuscinosis A subacute variant with onset in late childhood or in early period with seizures, ataxia, retinal lesions, mental failure, and gradual neurological deterioration. neuronal ceroid-lipofuscinosis type 7 (NCL-7) A group of previously unclassified atypical forms of NCL, representing about 12 to 20% of those afflicted, characterized by accumulation of ceroid-lipofuscin in the secondary lysosomes or neurons and cells of other tissues, as skin, conjunctiva, and lymphocytes.
Neuronal Plasticity definition: The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
25 further definitions >>
Publications
 

Copying and Evolution of Neuronal Topology

Chrisantha Fernando et al.

PLoS ONE , 20 Nov 2008

Hypothalamic neuronal responses to cytokines.

M. Shibata

The Yale Journal of Biology and Medicine , 1990

Atypical nucleosome spacing of rat neuronal identifier elements in non-neuronal chromatin.

I R Brown et al.

Nucleic Acids Research , 24 Apr 1987

Mechanisms of Neuronal Death in Synucleinopathy

Atsushi Takeda et al.

Journal of Biomedicine and Biotechnology , 2006

Neuronal activities related to thermoregulation.

T. Nakayama

The Yale Journal of Biology and Medicine , 1986

Neuronal mechanism for neuropathic pain

Min Zhuo

Molecular Pain , 06 Jun 2007

On the Dynamics of the Spontaneous Activity in Neuronal Networks

Alberto Mazzoni et al.

PLoS ONE , 09 May 2007

α-Synuclein and neuronal cell death

Mark R Cookson

Molecular Neurodegeneration , 04 Feb 2009

Runx transcription factors in neuronal development

Ken-ichi Inoue et al.

Neural Development , 26 Aug 2008

Isolation of neuronal chromatin from brain tissue

Yan Jiang et al.

BMC Neuroscience , 28 Apr 2008

1321 further publications >>