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As pregnancy-associated breast cancer (PABC) has a significantly more aggressive clinical course and mortality rate than other forms of breast malignancies, our current study compared tumor suppressor expression in myoepithelial cells of PABC and non-PABC, to determine whether myoepithelial cells of PABC may have aberrant expression of tumor suppressors.

Zheli Xu et al.

International Journal of Biological Sciences 5 (1), 09 Jan 2009

Tissue sections from 20 cases of PABC and 20 cases of stage, grade, and age matched non-PABC were subjected to immunohistochemistry, and the expression of tumor suppressor maspin, p63, and Wilms' tumor 1 (WT-1) in calponin positive myoepithelial cells were statistically compared.

Zheli Xu et al.

International Journal of Biological Sciences 5 (1), 09 Jan 2009

The expression profiles of maspin, p63, and WT-1 in myoepithelial cells of all ducts encountered were similar between PABC and non-PABC.

Zheli Xu et al.

International Journal of Biological Sciences 5 (1), 09 Jan 2009

PABC, however, displayed several unique alterations in terminal duct and lobular units (TDLU), acini, and associated tumor tissues that were not seen in those of non-PABC, which included the absence of p63 and WT-1 expression in a vast majority of the myoepithelial cells, cytoplasmic localization of p63 in the entire epithelial cell population of some lobules, and substantially increasing WT-1 expression in vascular structures of the invasive cancer component.

Zheli Xu et al.

International Journal of Biological Sciences 5 (1), 09 Jan 2009

Pregnancy-associated breast cancer (PABC) occurs during pregnancy or within one year of delivery.

Zheli Xu et al.

International Journal of Biological Sciences 5 (1), 09 Jan 2009

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