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Paroxetine definition: A serotonin uptake inhibitor that is effective in the treatment of depression.
paroxetine definition: serotonin uptake inhibitor used in the treatment of depression.
paroxetine hydrochloride definition: An antidepressant drug.
paroxetine hydrochloride definition: The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42793&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42793&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1837" NCI Thesaurus)
Paroxetine Hydrochloride definition: The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness.
Paroxetine Mesylate definition: The mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex, thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, which resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness.
 
Publications
 

Three year naturalistic outcome study of panic disorder patients treated with paroxetine

Pinhas N Dannon et al.

BMC Psychiatry , 11 Jun 2004

Even more suicide attempts in clinical trials with paroxetine randomised against placebo

Ivar Aursnes et al.

BMC Psychiatry , 28 Nov 2006

Suicide attempts in clinical trials with paroxetine randomised against placebo

Ivar Aursnes et al.

BMC Medicine , 22 Aug 2005

Quality of life and metabolic status in mildly depressed women with type 2 diabetes treated with paroxetine: A single-blind randomised placebo controlled trial

Maria Paile-Hyvärinen et al.

BMC Family Practice , 14 May 2003

Quality of life and metabolic status in mildly depressed patients with type 2 diabetes treated with paroxetine: A double-blind randomised placebo controlled 6-month trial

Maria Paile-Hyvärinen et al.

BMC Family Practice , 15 Jun 2007

Antidepressants and inflammatory bowel disease: a systematic review: ... publications included paroxetine, bupropion, ...

Antonina A Mikocka-Walus et al.

Clinical Practice and Epidemiology in Mental Health , 20 Sep 2006

Potentiation of Nerve Growth Factor-Induced Neurite Outgrowth by Fluvoxamine: Role of Sigma-1 Receptors, IP 3 Receptors and Cellular Signaling Pathways: ... sertraline, paroxetine) and three sigma-1 ...

Tomoko Nishimura et al.

PLoS ONE , 02 Jul 2008

Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor: ... acetaminophen, paroxetine, and ...

Jelena Radjenovic et al.

Analytical and Bioanalytical Chemistry , 01 Feb 2007

Alteration of serotonin transporter density and activity in fibromyalgia: ... measurement of [ 3 H]paroxetine binding and the [ 3 ...

Laura Bazzichi et al.

Arthritis Research & Therapy , 2006

QT interval prolongation related to psychoactive drug treatment: a comparison of monotherapy versus polytherapy: ... sertraline, paroxetine, fluvoxamine, ...

Michela Sala et al.

Annals of General Psychiatry , 25 Jan 2005

4 further publications >>