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Pentobarbital definition: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital definition: short to intermediate acting barbiturate used as a sedative and hypnotic; the sodium salt is also used as an anticonvulsant, as a preanesthetic and as an adjunct to anesthesia.
Pentobarbital Measurement definition: The determination of the amount of pentobarbital present in a sample.
Pentobarbital Sodium definition: The sodium salt of pentobarbital, a short-acting barbituric acid derivative with central nervous system (CNS) depressant property. Pentobarbital sodium binds to the gamma-aminobutyric acid (GABA)-A subtype receptor, resulting in modulation of chloride transport through receptor channels and potentiation of GABA-induced increases in chloride conductance. This enhances postsynaptic responses to the inhibitory actions of GABA and causes CNS depression. In addition, this agent inhibits glutamate induced nerve depolarization and depresses voltage-activated calcium currents.
 
Publications
 

Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial

Jon Pérez-Bárcena et al.

Critical Care , 2008

Oxidative metabolism in fetal rat brain during maternal halothane anesthesia.: ... rats were administered pentobarbital (50 or 200 mg/kg). Dams ...

R C Vannucci et al.

Environmental Health Perspectives , 01 Dec 1977

Improvement of Impaired Memory in Mice by Taurine: ... chemical agents (pentobarbital, cycloheximide, sodium ...

Bhupinder P. S. Vohra et al.

Neural Plasticity , 2000

Coincident Activity of Converging Pathways Enables Simultaneous Long-Term Potentiation and Long-Term Depression in Hippocampal CA1 Network In Vivo: ... we report that, in pentobarbital-anesthetized rats, ...

ZhiFang Dong et al.

PLoS ONE , 06 Aug 2008

Multiple synaptic and membrane sites of anesthetic action in the CA1 region of rat hippocampal slices: ... on glutamate synapses-pentobarbital depressed transmission ...

Sky Pittson et al.

BMC Neuroscience , 03 Dec 2004

Effects of fluorocarbons, chlorinated solvents, and inosine on the cardiopulmonary system: ... dogs anesthetized with pentobarbital sodium. Methylene ...

Domingo M. Aviado

Environmental Health Perspectives , 01 Oct 1978

Impact of ε and θ subunits on pharmacological properties of α3β1 GABA A receptors expressed in Xenopus oocytes: ... flurazepam, but not by pentobarbital. Furthermore, the α3β1ε ...

Martin Ranna et al.

BMC Pharmacology , 13 Jan 2006

Non-Invasive monitoring of diaphragmatic timing by means of surface contact sensors: An experimental study in dogs: ... an animal model: three pentobarbital anesthetized mongrel ...

José Antonio Fiz et al.

BMC Pulmonary Medicine , 08 Sep 2004

Short reflex expirations (expiration reflexes) induced by mechanical stimulation of the trachea in anesthetized cats: ... spontaneously breathing pentobarbital-anesthetized cats were ...

Ivan Poliacek et al.

Cough (London, England) , 28 Apr 2008

The use of ferrokinetics in the study of experimental anemia.: ... and (2) effect of pentobarbital on the toxic action of ...

E W Lee et al.

Environmental Health Perspectives , 01 Jun 1981

8 further publications >>