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Definition
 
enEnglish
Potassium Perchlorate definition: The potassium salt of perchloric acid and a member of the Hofmeister ions series with thyroid blocking properties. Potassium perchlorate is a competitive inhibitor of iodine uptake through inhibiting the sodium-iodide symporter (NIS) on the thyroid follicular cell membrane. This results in a potential decrease in thyroid hormone synthesis including thyroxine (T4) and tri-iodothyronine (T3). In addition, this agent decreases the accumulation of the radioactive imaging substance and Hofmeister series ion, pertechnetate Tc 99m, in the choroid plexus and in the salivary and thyroid glands through competitive displacing.
 
frFrench
perchlorate definition: Nom générique des sels d’acide perchlorique ; anion de formule ClO4-.
 
Publications
 

The NAS Perchlorate Review: Questions Remain about the Perchlorate RfD

Gary Ginsberg et al.

Environmental Health Perspectives , 01 Sep 2005

Benchmark Calculations for Perchlorate from Three Human Cohorts

Kenny S. Crump et al.

Environmental Health Perspectives , 01 Aug 2005

Genetic Factors That Might Lead to Different Responses in Individuals Exposed to Perchlorate

Franco Scinicariello et al.

Environmental Health Perspectives , 01 Nov 2005

Effects of Ammonium Perchlorate on Thyroid Function in Developing Fathead Minnows, Pimephales promelas

Helen M. Crane et al.

Environmental Health Perspectives , 01 Apr 2005

Temporal Patterns in Perchlorate, Thiocyanate, and Iodide Excretion in Human Milk

Andrea B. Kirk et al.

Environmental Health Perspectives , 01 Feb 2007

Intersubject Variability of Risk from Perchlorate in Community Water Supplies

Doug Crawford-Brown et al.

Environmental Health Perspectives , 01 Jul 2006

Development of a Health-Protective Drinking Water Level for Perchlorate

David Ting et al.

Environmental Health Perspectives , 01 Jun 2006

Developmental Exposure to Perchlorate Alters Synaptic Transmission in Hippocampus of the Adult Rat

Mary E. Gilbert et al.

Environmental Health Perspectives , 01 Jun 2008

Urinary Perchlorate and Thyroid Hormone Levels in Adolescent and Adult Men and Women Living in the United States

Benjamin C. Blount et al.

Environmental Health Perspectives , 01 Dec 2006

Health effects assessment for environmental perchlorate contamination: the dose response for inhibition of thyroidal radioiodine uptake in humans.

Monte A Greer et al.

Environmental Health Perspectives , 01 Sep 2002

19 further publications >>