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Pregnanolone definition: A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.
pregnanolone definition: pregnane found in the urine of pregnant women and sows; has anesthetic, hypnotic, and sedative properties.
 
Examples
 

In the presence of EC 25 GABA, introduction of the ε subunit to the receptor complex resulted in diminished modulatory effects by etomidate, propofol, pregnanolone and flurazepam, but not by pentobarbital.

Martin Ranna et al.

BMC Pharmacology 6 (7), 13 Jan 2006

The values are means ± standard errors (n = 6 for α3β1; n = 9 for α3β1γ2; n = 6 for α3β1θ; n = 7 for α3β1ε and n = 3 for α3β1θε receptors). ε and θ subunits reduce neurosteroid potency In the presence of 1 μM pregnanolone, GABA-induced currents were 152 ± 5 % of the control GABA response for α3β1 (mean ± standard error, n = 6), 177 ± 6 % for α3β1γ2 (n = 5), 135 ± 4 % for α3β1θ (n = 5), 119 ± 8 % for α3β1ε (n = 6) and 158 ± 4 % for α3β1εθ (n = 4) receptors, indicating that γ2 subunit-containing receptors were slightly more potentiated by pregnanolone than α3β1 receptors ( p < 0.05, Dunnett's test).

Martin Ranna et al.

BMC Pharmacology 6 (7), 13 Jan 2006

Nonlinear regression fit of pregnanolone potentiation of GABA-induced currents yielded remarkable differences in pregnanolone potency as α3β1γ2 receptors were highly sensitive and robustly potentiated by pregnanolone [EC 50 47 nM and maximal potentiation 182 ± 10 % (Fig.

Martin Ranna et al.

BMC Pharmacology 6 (7), 13 Jan 2006

Sensitivities to the neurosteroid pregnanolone .

Martin Ranna et al.

BMC Pharmacology 6 (7), 13 Jan 2006

Modulation of GABA-induced currents by the neurosteroid pregnanolone in recombinant GABA A receptors expressed in Xenopus oocytes.

Martin Ranna et al.

BMC Pharmacology 6 (7), 13 Jan 2006

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