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The aim of this study was to use carbon-11 labelled ethyl and propyl iodide with high specific radioactivity in the synthesis of two new and potentially reversible NK 1 -receptor ligands with chemical structures based on [ O - methyl - 11 C]GR205171.

Stina Syvänen et al.

BMC Medical Imaging 7 (7), 30 Jul 2007

[1- 11 C]Ethyl and [1- 11 C]propyl iodide with specific radioactivities of 90 GBq/μmol and 270 GBq/μmol, respectively, were used in the synthesis of [ O - methyl - 11 C]GR205171 analogues by alkylation of O -desmethyl GR205171.

Stina Syvänen et al.

BMC Medical Imaging 7 (7), 30 Jul 2007

The aim of this study was to use labelled ethyl and propyl iodide with high specific radioactivity in the synthesis of [ O - methyl - 11 C]GR205171-analogues with different alkyl chain lengths and to compare the binding characteristics in guinea pig and rhesus monkey.

Stina Syvänen et al.

BMC Medical Imaging 7 (7), 30 Jul 2007

The ethyl analogue (2 S ,3 S )- N -(1-(2- [1- 11 C]ethoxy-5-(3-(trifluoromethyl)-4 H The ethyl analogue (2 S ,3 S )- N -(1-(2- [1- 11 C-]ethoxy-5-(3-(trifluoromethyl)-4 H -1,2,4-triazol--4-yl)phenyl)ethyl)-2-phenylpiperidin-3-amine (I) - and the propyl analogue (2 S ,3 S )-2-phenyl- N --(1-(2- [1- 11 C]propoxy-5-(3-(trifluoromethyl)-4 H- -1,2,4-triazol-4-yl)phenyl)ethyl)piperidin-3-amin-e (II) were synthesized via alkylation of O -de-smethyl GR205171 with [1- 11 C]ethyl iodide and [1-- 11 C]propyl iodide, Figure 1 . (I) and the propyl analogue (2 S ,3 S )-2-phenyl- N -(1-(2- [1- 11 C]propoxy-5-(3-(trifluoromethyl)-4 H -1,2,4-triazol-4-yl)phenyl)ethyl)piperidin-3-amine (II) were synthesized via alkylation of O -desmethyl GR205171 with [1- 11 C]ethyl iodide and [1- 11 C]propyl iodide, Figure 1 .

Stina Syvänen et al.

BMC Medical Imaging 7 (7), 30 Jul 2007

The solution was vortexed for approximately 20 min before [1- 11 C]ethyl iodide or [1- 11 C]propyl iodide was transferred in a flow of nitrogen gas (30 mL/min) to the vial.

Stina Syvänen et al.

BMC Medical Imaging 7 (7), 30 Jul 2007