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Protein Phosphatase 2 Regulatory Subunit B Delta definition: Widely expressed (high in brain) as 3 isoforms by human PPP2R5D Gene (PP2A Subunit B Family), 70-kDa Protein Phosphatase 2 Regulatory Subunit B Delta is a cytoplasmic and nuclear regulatory subunit of PP2A in interphase, but nuclear in mitosis. PPP2R5D-1 is serine phosphorylated. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI)
 
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