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Protein Phosphatase 2 Catalytic Subunit Alpha definition: Encoded by human PPP2CA Gene (PP1 Family), 309-aa 36-kDa cytoplasmic Protein Phosphatase 2 Catalytic Subunit Alpha forms alpha complexes with a structural PR65/A subunit and beta complexes with an alpha4 protein; association with a regulatory subunit that controls substrate selectivity and activity forms as a specific trimeric holoenzyme. PPP2CA is regulated by inactivating threonine or tyrosine phosphorylation, carboxy methylation, ceramide, and protein inhibitors. Carboxyl methylation may play a role in holoenzyme assembly; it varies during the cell cycle. PP2A can dephosphorylate p53, and modulate phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP2 kinase activity. Core PP2A enzyme consists of the catalytic subunit and a common 65-kDa regulatory subunit; additional regulatory subunits or signaling molecules further modify function. (NCI)
 
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