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Definition
 
enEnglish
Interleukin-5 definition: A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.
interleukin 5 definition: lymphokine produced by antigen or mitogen activated T lymphocytes that acts as a differentiation factor for B lymphocytes and eosinophils and increases the production of IgA by B lymphocytes.
Interleukin-5 definition: Human interleukin-5 protein (134 aa, 15 kDa precursor) is encoded by the human interleukin-5 (IL5) gene. This cytokine acts as a growth and differentiation factor for eosinophils and induces terminal differentiation of B-cells which become Ig-secreting cells. It is thought to play a pivotal role in the pathogenesis of asthma. Elevated levels of this protein have been detected in both asthma and hypereosinophilic syndromes.
IL5 Gene definition: This gene plays a role in eosinophil differentiation.
Recombinant Interleukin-5 definition: A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-5 (IL-5). Produced by T cells, IL-5 stimulates the growth, differentiation, and activation of eosinophils, and promotes the conversion of B-cells into antibody- producing cells. (NCI04)
IL5 wt Allele definition: Human IL5 wild-type allele is located in the vicinity of 5q31.1 and is approximately 2 kb in length. This allele, which encodes interleukin-5 protein, is involved in eosinopoiesis or eosinophil maturation and activation.
 
Examples
 

It was suggested from data which we and others have previously reported that various sequences could be capable of activating c-raf(-1) by replacing its 5' half.

T Tahira et al.

Nucleic Acids Research 15 (12), 25 Jun 1987

We have cloned cDNA for T-cell replacing factor (interleukin-5), which replaces T-cell helper function for normal B cells which secrete immunoglobulin, from human T cell leukemia line, ATL-2, using mouse interleukin-5 cDNA as probe.

C Azuma et al.

Nucleic Acids Research 14 (22), 25 Nov 1986

7-Deaza-2′-deoxyadenosine (1, c 7 A d ) and 3-deaza-2′-deoxyadenosine (2, c 3 A d ) have been incorporated into d(AAAAAA) tracts replacing dA at various positions within oligonucleotides.

Frank Seela et al.

Nucleic Acids Research 20 (9), 11 May 1992

To pass the tumor the procedure described in case 1 was applied after replacing the colonoscope by the baby gastroscope (figure 3C ).

Giuliano Ramadori et al.

BMC Gastroenterology 7 (7), 28 Mar 2007

Polypoid parts of the tumor are removed with the snare (B), and after replacing the colonoscope by a baby endoscope, first a soft wire and then, guided by the wire, the baby gastroscope is pushed through the stenosis (C), the scope is withdrawn, leaving the wire in place, an ERCP catheter is pushed over the wire to stabilize it, and finally a conventional gastroscope that has a working channel wide enough to use a APC probe is pushed beyond the stenosis via the ERCP catheter and the wire.

Giuliano Ramadori et al.

BMC Gastroenterology 7 (7), 28 Mar 2007

222 further examples >>
Publications
 

Activation of human c-raf-1 by replacing the N-terminal region with different sequences.

T Tahira et al.

Nucleic Acids Research , 25 Jun 1987

Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue.

C Azuma et al.

Nucleic Acids Research , 25 Nov 1986

7-Deaza-2′-deoxyadenosine and 3-deaza-2′-deoxyadenosine replacing dA within d(A 6 )-tracts: differential bending at 3′- and 5′-junctions of d(A 6 )·d(T 6 ) and B-DNA

Frank Seela et al.

Nucleic Acids Research , 11 May 1992

PCR with 5-methyl-dCTP replacing dCTP.

K K Wong et al.

Nucleic Acids Research , 11 Mar 1991

Replacing the projected retiring baby boomer nursing cohort 2001 – 2026

Deborah J Schofield

BMC Health Services Research , 16 Jun 2007

Colorectal tumors with complete obstruction – Endoscopic recovery of passage replacing emergency surgery? A report of two cases

Giuliano Ramadori et al.

BMC Gastroenterology , 28 Mar 2007

Replacing a Swiss ball for an exercise bench causes variable changes in trunk muscle activity during upper limb strength exercises

Gregory J Lehman et al.

Dynamic medicine : DM , 03 Jun 2005

Research influence on antimalarial drug policy change in Tanzania: case study of replacing chloroquine with sulfadoxine-pyrimethamine as the first-line drug

Godfrey M Mubyazi et al.

Malaria Journal , 20 Oct 2005

Replacing tryptophan-128 of T4 endonuclease V with a serine residue results in decreased enzymatic activity in vitro and in vivo.

K Valerie

Nucleic Acids Research , 25 Sep 1995

C4-methyldeoxythymidine replacing deoxythymidine in poly[d(A-T)] renders the polymer resistant to the 3'----5' exonuclease activity of the Klenow and T4 DNA polymerases.

B Singer

Nucleic Acids Research , 26 Aug 1986

217 further publications >>