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Translation
 
enEnglish deGerman
1 word
specificity Genauigkeit (im Detail)
specificity Spezifität
 
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enEnglish frFrench
1 word
specificity particularité
specificity spécificité
 
enEnglish ioIdo
1 word
specificity specifikeso
 
Definition
 
enEnglish
Antibody Specificity definition: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
antibody specificity definition: property of antibodies which enables them to react with some antigenic determinants and not with others; specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Organ Specificity definition: Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
Sensitivity and Specificity definition: Measures for assessing the results of diagnostic and screening tests. Sensitivity represents the proportion of truly diseased persons in a screened population who are identified as being diseased by the test. It is a measure of the probability of correctly diagnosing a condition. Specificity is the proportion of truly nondiseased persons who are so identified by the screening test. It is a measure of the probability of correctly identifying a nondiseased person. (From Last, Dictionary of Epidemiology, 2d ed)
Species Specificity definition: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Substrate Specificity definition: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Dual Specificity Phosphatase 1 definition: A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for P38 MITOGEN-ACTIVATED PROTEIN KINASES and JNK MITOGEN-ACTIVATED PROTEIN KINASES.
Cell Division Cycle 2-Like 1 definition: Cell Division Cycle 2-Like 1, encoded by the CDC2L1 gene, is a member of the p34Cdc2 serine/threonine protein kinase family. CDC2L1 is expressed ubiquitously and acts as a negative regulator of the normal cell cycle progression. It may function in regulating proliferation by phosphorylation and subsequent plasma membrane targeting of galactosyltransferase. This gene is deleted or altered frequently in neuroblastoma with amplified MYCN genes. CDC2L1 can be cleaved by caspases and play roles in cell apoptosis. A large number of the alternatively spliced variants of this gene exist. (From LocusLink, Swiss-Prot and NCI)
Cleavage And Polyadenylation Specificity Factor definition: An RNA-binding protein that recognizes the AAUAAA RNA SEQUENCE at the 3' end of MRNA. It contains four subunits of 30, 73, 100 and 160 kDa molecular size and combines with CLEAVAGE STIMULATION FACTOR to form a stable complex with mRNA that directs the 3' cleavage and polyadenylation reaction.
Cyclin-Dependent Kinase Inhibitor 3 definition: Cyclin-Dependent Kinase Inhibitor 3, encoded by the CDKN3 gene, is a dual-specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. This protein is a cyclin-dependent kinase inhibitor and may play a role in cell cycle regulation. It has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. Delay of cell cycle progression is dependent on CDKN3 phosphatase activity. This protein also interacts with other cyclin-dependent kinases such as CDC2 and CDK3, but not with CDK4. The CDKN3 gene is deleted, mutated, or overexpressed in several kinds of cancers. Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC). (From LocusLink, Swiss-Prot, OMIM and NCI)
19 further definitions >>
frFrench
spécificité definition: Caractère spécifique de quelque chose, caractère qui est propre spécialement à quelque chose.
spécificité definition: Probabilité, dans un test binaire, d'identifier correctement un vrai négatif.
 
Publications
 

The base-pairing specificity of cellulose-pdT9.

S Gillam et al.

Nucleic Acids Research , 01 May 1975

DNA sequence specificity of mitoxantrone.

C Panousis et al.

Nucleic Acids Research , 25 Apr 1994

The cleavage specificity of RNase III.

L Krinke et al.

Nucleic Acids Research , 25 Aug 1990

Isochores and tissue-specificity

Alexander E. Vinogradov

Nucleic Acids Research , 01 Sep 2003

A theoretical framework for specificity in cell signaling

Natalia L Komarova et al.

Molecular Systems Biology , 18 Oct 2005

A Specificity Map for the PDZ Domain Family

Raffi Tonikian et al.

PLoS Biology , 01 Sep 2008

The sequence specificity domain of cytosine-C5 methylases.

S Klimasauskas et al.

Nucleic Acids Research , 25 Nov 1991

The sequence specificity of vertebrate DNA methylation.

M J Browne et al.

Nucleic Acids Research , 01 Apr 1977

The sequence specificity of a mammalian DNA methylase.

M J Browne et al.

Nucleic Acids Research , 01 Apr 1977

Design of Multi-Specificity in Protein Interfaces

Elisabeth L Humphris et al.

PLoS Computational Biology , 01 Aug 2007

3609 further publications >>