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Cerebral and extracranial Lewy body type-degeneration in PD do not develop independently from each other but develop in a strongly coupled manner.

Jörg Spiegel et al.

The Open Neurology Journal 1 (7), 22 Aug 2007

CONCLUSIONS Our data indicate a strongly coupled degeneration of ni-grostriatal dopaminergic and myocardial sympathetic transmission at early as well as advanced stages of PD.

Jörg Spiegel et al.

The Open Neurology Journal 1 (7), 22 Aug 2007

Our results give strong evidence that the clinically and histopathologically manifest cerebral and extracranial degenerative changes in PD do not develop independently from each other but develop in a strongly coupled manner.

Jörg Spiegel et al.

The Open Neurology Journal 1 (7), 22 Aug 2007

Results Here we introduce a method relying on gene annotation coupled to decompositional analysis of global gene expression data that allows us to estimate specific activity on strongly coupled signaling pathways and, in some cases, activity of specific signaling proteins.

Ghislain Bidaut et al.

BMC Bioinformatics 7 (7), 28 Feb 2006

Using gene ontology and data on gene regulation in the Saccharomyces Genome Database, we identified the transcriptional signatures of several cellular processes in yeast, including cell wall creation, ribosomal disruption, chemical blocking of protein synthesis, and, criticially, individual signatures of the strongly coupled mating and filamentation pathways.

Ghislain Bidaut et al.

BMC Bioinformatics 7 (7), 28 Feb 2006

3293 further examples >>
Publications
 

Cerebral and Extracranial Neurodegeneration are Strongly Coupled in Parkinson’s Disease

Jörg Spiegel et al.

The Open Neurology Journal , 22 Aug 2007

Determination of strongly overlapping signaling activity from microarray data

Ghislain Bidaut et al.

BMC Bioinformatics , 28 Feb 2006

Genomic characterization of a repetitive motif strongly associated with developmental genes in Drosophila

Javier Costas et al.

BMC Genomics , 16 Dec 2003

Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study

L. W. de Jong et al.

Brain , 01 Dec 2008

A non-curved chicken lysozyme 5' matrix attachment site is 3' followed by a strongly curved DNA sequence.

J P von Kries et al.

Nucleic Acids Research , 11 Jul 1990

Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener's granulomatosis

Holger Brockmann et al.

Arthritis Research , 2002

Transcriptional activation of NFI/CTF1 depends on a sequence motif strongly related to the carboxyterminal domain of RNA polymerase II.

W Wendler et al.

Nucleic Acids Research , 11 Jul 1994

The reactivity of phosphodiester bonds within linear single-stranded oligoribonucleotides is strongly dependent on the base sequence

Ulla Kaukinen et al.

Nucleic Acids Research , 15 Jan 2002

Infection by Mycoplasma hyorhinis strongly enhances uptake of antisense oligonucleotides: a reassessment of receptor-mediated endocytosis in the HepG2 cell line

Philippe de Diesbach et al.

Nucleic Acids Research , 01 Feb 2003

Linkage structures strongly influence the binding cooperativity of DNA intercalators conjugated to triplex forming oligonucleotides.

F M Orson et al.

Nucleic Acids Research , 11 Feb 1994

3288 further publications >>