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Definition
 
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Mutagenesis, Site-Directed definition: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
site directed mutagenesis definition: mutagenesis where the mutation is caused by in vitro induction directed at a specific site in a DNA molecule; the most common method involves use of a chemically synthesized oligonucleotide mutant which can hybridize with the DNA target molecule; the resulting mismatch-carrying DNA duplex may then be transfected into a bacterial cell line and the mutant strands recovered.
Targeted Mutation definition: A mutation created in a gene at a specific location.
Site-Directed Mutagenesis definition: Any of several methods used to create alterations in a gene at a specific location.
Targeted Fusion Protein Therapy definition: Drug therapy in which the drug is a fusion protein generated by molecular biology procedures. The fusion protein combines a cell targeting moiety, such as an antibody fragment, with an effector moiety, like a bacterial toxin.
Targeting definition: The process of directing an agent to a specific anatomic location.
doxorubicin-magnetic targeted carrier complex definition: Anthracycline antineoplastic antibiotic doxorubicin bound to microscopic beads of activated carbon and iron (magnetic targeted carriers). With placement of a magnet on the body surface overlying a tumor site, this carrier complex delivers doxorubicin directly to the tumor, thereby prolonging the duration of the therapeutic effects while decreasing its systemic toxicity. Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38388&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38388&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2644" NCI Thesaurus)
Doxorubicin-Magnetic Targeted Carrier Complex definition: A formulation of the anthracycline antibiotic doxorubicin in which doxorubicin is bound to microscopic beads of activated carbon and iron as a magnetic-targeted carrier (MTC). Doxorubicin, an intercalator and a topoisomerase II inhibitor, prevents DNA replication and ultimately inhibits protein synthesis. This agent also generates oxygen free radicals, resulting in cytotoxic lipid peroxidation of cell membrane lipids. Guided by the placement of a magnet on the body surface overlying a tumor site, the doxorubicin-MTC complex delivers doxorubicin directly to the tumor site, thereby targeting and prolonging the duration of doxorubicin-mediated cytotoxicity to the tumor bed while minimizing systemic toxicity.
CNGRC Peptide-TNF Alpha Conjugate definition: A cytokine-peptide conjugate composed of the cytokine tumor necrosis factor alpha (TNF-alpha) chemically linked to the peptide CNGRC. The peptide moiety CNGRC, a ligand for the membrane-bound metalloprotease CD13, binds to endothelial cells of the angiogenic vasculature that express CD13 (also known as aminopeptidase N); subsequently, the TNF-alpha moiety induces apoptosis in endothelial cells expressing CD13, thereby inhibiting tumor-associated angiogenesis. (NCI05)
CNGRC peptide-TNF alpha conjugate definition: A cytokine-peptide conjugate composed of the cytokine tumor necrosis factor alpha (TNF-alpha) chemically linked to the peptide CNGRC. The peptide moiety CNGRC, a ligand for the membrane-bound metalloprotease CD13, binds to endothelial cells of the angiogenic vasculature that express CD13 (also known as aminopeptidase N); subsequently, the TNF-alpha moiety induces apoptosis in endothelial cells expressing CD13, thereby inhibiting tumor-associated angiogenesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=403156&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=403156&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48383" NCI Thesaurus)
19 further definitions >>
Publications
 

Targeted Delivery of siRNA

Sabrina Oliveira et al.

Journal of Biomedicine and Biotechnology , 2006

The management of cancer in the elderly: targeted therapies in oncology

Biagio Agostara et al.

Immunity & Ageing : I & A , 30 Dec 2008

Targeted gene walking polymerase chain reaction.

J D Parker et al.

Nucleic Acids Research , 11 Jun 1991

Molecular targeted therapies for breast cancer treatment

Claus M Schlotter et al.

Breast Cancer Research : BCR , 2008

Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma

Kimberly A Kelly et al.

PLoS Medicine , 01 Apr 2008

Targeted mutagenesis of DNA with alkylating RecA assisted oligonucleotides.

M J Singer et al.

Nucleic Acids Research , 15 Dec 1999

probeBase: an online resource for rRNA-targeted oligonucleotide probes

Alexander Loy et al.

Nucleic Acids Research , 01 Jan 2003

Targeted development of informative microsatellite (SSR) markers

M. J. Hayden et al.

Nucleic Acids Research , 15 Apr 2001

Effect of Cellular Quiescence on the Success of Targeted CML Therapy

Natalia L. Komarova et al.

PLoS ONE , 03 Oct 2007

Bacterial flora-typing with targeted, chip-based Pyrosequencing

Andreas Sundquist et al.

BMC Microbiology , 30 Nov 2007

2109 further publications >>