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Topoisomerase III definition: Topoisomerase III belongs to type IA topoisomerases subfamily (includes archaebacterial reverse gyrase, bacterial topo I and topo III, which all form covalent 5'phosphotyrosine linkage with cleaved DNA). Topo III does not play a major role in regulating DNA supercoiling, however, genetic experiments implicate that it plays a role in suppressing mitotic recombination and in resolving recombined homologous chromosomes during meiosis I. Topo III also has been demonstrated to interact with RecQ family of DNA helicases, which includes the Bloom's syndrome, Werner's syndrome, and Rothmund-Thomson syndrome gene products.
TOP3A Gene definition: This gene plays a role in the regulation of DNA topology and recombination in somatic cells.
Topoisomerase III Alpha definition: Expressed in multiple somatic tissues (highest in testis, heart, skeletal muscle, pancreas), human TOP3 Gene (TOPI/III Family) encodes long (1001-aa, 112-kD) and short (976-aa) alternative DNA Topoisomerase III Alpha isoforms that share no homology with DNA TOPI. TOP3A catalyzes transient ATP-independent breaking/rejoining of single DNA strands, reducing negative supercoils and controlling DNA topology during transcription. The enzyme forms a complex with BLM (aa 1-133 of BLM), which recruits TOP3A to PML nuclear bodies and regulates somatic sister chromatid recombination. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Topoisomerase III Alpha definition: Topoisomerase III alpha is involved in rDNA metabolism, such as rDNA transcription. It exhibits homology to the Escherichia coli DNA topoisomerase I subfamily of enzymes and shares no significant sequence homology with eukaryotic DNA topoisomerase I. Topo III-alpha interacts with the N-terminus of BLM and is recruited to PML nuclear bodies. Evidence suggest that the BLM/TOP3A complex may be involved in the regulation of recombination between sister chromatids in somatic cells. (from OMIM 601243 and NCI)
RecQ helicase-Topo III complex definition: A complex containing a RecQ family helicase and a topoisomerase III homologue; may also include one or more additional proteins; conserved from E. coli to human. [PMID:15889139]
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