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topoisomerase II inhibitor RTA 744 definition: An anthracycline derivative with potential antitumor activity. RTA 744 intercalates into DNA and interrupts topoisomerase II activity, thereby inhibits DNA replication and repair, as well as RNA and protein synthesis. Unlike other anthracycline derivatives, RTA 744 crosses the blood-brain barrier and reaches therapeutic levels in the brain. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=491929&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=491929&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61568" NCI Thesaurus)
 
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