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Transmembrane Protein definition: A protein that is an integral membrane protein with a transmembrane region.
Membrane Potentials definition: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
membrane potential definition: electrical potential difference across a biological, i.e., cell or organelle, or artificial membrane.
DEAD/H Box Protein 26 definition: Encoded by human DDX26 Gene (DEAD Family), the highly conserved candidate tumor suppressor 1687-amino acid 188.5-kD DEAD/H Box Protein 26 contains a vWF type A domain. With a likely important cellular function, DDX26 is expressed in a variety of fetal and adult tissues. DEAD box proteins, characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)
cellobiose transmembrane transporter activity definition: Catalysis of the transfer of cellobiose from one side of the membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose. [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
fructose transmembrane transporter activity definition: Catalysis of the transfer of fructose from one side of the membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
galactitol transmembrane transporter activity definition: Catalysis of the transfer of a galactitol from one side of the membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
galactosamine transmembrane transporter activity definition: Catalysis of the transfer of galactosamine from one side of the membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative. [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
glucose transmembrane transporter activity definition: Catalysis of the transfer of the hexose monosaccharide glucose from one side of the membrane to the other. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
amine transmembrane transporter activity definition: Catalysis of the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
69 further definitions >>
Examples
 

An important subfamily of membrane proteins are the transmembrane α-helical proteins, in which the membrane-spanning regions are made up of α-helices.

Jack Y Yang et al.

BMC Genomics 9 (Suppl 1), 20 Mar 2008

Given the obvious biological and medical significance of these proteins, it is of tremendous practical importance to identify the location of transmembrane segments.

Jack Y Yang et al.

BMC Genomics 9 (Suppl 1), 20 Mar 2008

The difficulty of inferring the secondary or tertiary structure of transmembrane proteins using experimental techniques has led to a surge of interest in applying techniques from machine learning and bioinformatics to infer secondary structure from primary structure in these proteins.

Jack Y Yang et al.

BMC Genomics 9 (Suppl 1), 20 Mar 2008

We are therefore interested in determining which physicochemical properties are most useful for discriminating transmembrane segments from non-transmembrane segments in transmembrane proteins, and for discriminating intrinsically unstructured segments from intrinsically structured segments in transmembrane proteins, and in using the results of these investigations to develop classifiers to identify transmembrane segments in transmembrane proteins.

Jack Y Yang et al.

BMC Genomics 9 (Suppl 1), 20 Mar 2008

We determined that the most useful properties for discriminating transmembrane segments from non-transmembrane segments and for discriminating intrinsically unstructured segments from intrinsically structured segments in transmembrane proteins were hydropathy, polarity, and flexibility, and used the results of this analysis to construct classifiers to discriminate transmembrane segments from non-transmembrane segments using four classification techniques: two variants of the Self-Organizing Global Ranking algorithm, a decision tree algorithm, and a support vector machine algorithm.

Jack Y Yang et al.

BMC Genomics 9 (Suppl 1), 20 Mar 2008

606 further examples >>
Publications
 

Investigation of transmembrane proteins using a computational approach

Jack Y Yang et al.

BMC Genomics , 20 Mar 2008

TRAMPLE: the transmembrane protein labelling environment

Piero Fariselli et al.

Nucleic Acids Research , 01 Jul 2005

TOPDB: topology data bank of transmembrane proteins

Gábor E. Tusnády et al.

Nucleic Acids Research , 01 Jan 2008

Predicting transmembrane beta-barrels in proteomes

Henry R. Bigelow et al.

Nucleic Acids Research , 2004

Transmembrane Protein Oxygen Content and Compartmentalization of Cells

Rajkumar Sasidharan et al.

PLoS ONE , 16 Jul 2008

[email protected]: a web application for the analysis of transmembrane helix mobility

Lars Skjaerven et al.

BMC Bioinformatics , 02 Jul 2007

Mining the Arabidopsis thaliana genome for highly-divergent seven transmembrane receptors

Etsuko N Moriyama et al.

Genome Biology , 2006

Glycosylation and the cystic fibrosis transmembrane conductance regulator

Thomas F Scanlin et al.

Respiratory Research , 2001

A Specific Interface between Integrin Transmembrane Helices and Affinity for Ligand

Bing-Hao Luo et al.

PLoS Biology , 01 Jun 2004

IgTM: An algorithm to predict transmembrane domains and topology in proteins

Piedachu Peris et al.

BMC Bioinformatics , 10 Sep 2008

601 further publications >>