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Triple Functional Domain Protein definition: Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney, and lung by human TRIO Gene (Ser/Thr Kinase Family), 3038-aa 342-kDa serine phosphorylated Triple Functional Domain Protein contains a Ser/Thr kinase domain, 2 DH domains, a CRAL-TRIO domain, an Ig-like C2-type domain, 2 PH domains, an SH3 domain, and 4 spectrin repeats. The N-terminal DBL(DH)/GEF domain catalyzes RAC1 GDP/GTP exchange, leading to JUN kinase activation and membrane ruffling. The second DBL(DH)/GEF domain catalyzes RHOA GDP/GTP exchange, inducing stress fiber formation. Interacting with the cytoplasmic region of LAR tyrosine phosphatase, TRIO may coordinate cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth. (NCI)
 
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