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Definition
 
enEnglish
Q2S definition: Every two weeks. (NCI)
Every Two Weeks definition: Every two weeks.
 
Examples
 

The half-life of epoetin delta suggests that administration of this agent is feasible once weekly and once every two weeks.

Iain C Macdougall

Trials 8 (7), 13 Nov 2007

We report on the design and rationale of a trial to compare once weekly vs . twice weekly, and once weekly vs . once every two weeks dosing of epoetin delta.

Iain C Macdougall

Trials 8 (7), 13 Nov 2007

There are two primary objectives of this trial: 1) to demonstrate non-inferiority between twice weekly and once weekly dosing of epoetin delta in previously naïve patients (assessed by haemoglobin at Week 24); 2) to demonstrate non-inferiority between once weekly and once every two weeks dosing in previously stable patients (assessed by average haemoglobin over Weeks 16–24).

Iain C Macdougall

Trials 8 (7), 13 Nov 2007

To demonstrate non-inferiority between QW and once every two weeks (Q2W) dosing in patients previously stable on an ESA, as assessed by average haemoglobin over Weeks 16–24.

Iain C Macdougall

Trials 8 (7), 13 Nov 2007

Table 1 Major selection criteria Inclusion criteria • Patients aged at least 18 years of age with CKD (KDOQI Stage 3–5) who are able to give written informed consent and are likely to attend all study visits • Stable on any dose ≤ 10 000 IU/week of subcutaneous ESA or requiring initiation of ESA treatment • Those currently receiving ESA treatment must have been receiving a stable dose, that was effective in managing haemoglobin levels (≥ 11 g/dL), for at least 30 days before randomization in the study • Those requiring initiation of ESA treatment must have haemoglobin levels ≥ 8 g/dL and < 11 g/dL • Transferrin saturation ≥ 20 % and ferritin ≥ 100 ng/mL Major exclusion criteria • Uncontrolled hypertension • Requiring doses of ESA > 10 000 IU/week • Two or more doses of prescribed ESA treatment missed or withheld by physician order in the 14 days immediately before randomization in the study • Thrombocytopenia (platelet count < 75 000/mm 3 ) • Active bleeding disorder (diathesis) (for example, gastro-intestinal or genito-urinary tract bleeding) • Treatment with immunosuppressive drugs (other than corticosteroids for a chronic condition) in the 30 days immediately before randomization in the study • Androgen therapy in the 30 days immediately before randomization in the study • Known HIV infection from medical history • Known or suspected intolerance or hypersensitivity to ESA therapy or to any of the excipients of epoetin delta • Known to have antibodies against erythropoietin • Impaired hepatic function (AST, ALT > 3x ULN) Study treatments All patients will receive epoetin delta, administered subcutaneously, for a maximum of 24 weeks.

Iain C Macdougall

Trials 8 (7), 13 Nov 2007

274 further examples >>
Publications
 

Comparison of different dosing regimens (once weekly vs . twice weekly, and once weekly vs . once every two weeks) with epoetin delta in patients with chronic kidney disease: a randomized controlled trial

Iain C Macdougall

Trials , 13 Nov 2007

Uterine mullerian adenosarcoma with sarcomatous overgrowth fatal recurrence within two weeks of diagnosis: a case report

Mirna H Farhat et al.

Journal of Medical Case Reports , 25 Sep 2007

Metabolic Alterations in Obstructive Jaundice: Effect of Duration of Jaundice and Bile-Duct Decompression: ... (4 days, one week, and two weeks) and following ...

R. N. Younes et al.

HPB Surgery , 1991

The “Incubation Period” of Subacute Bacterial Endocarditis: ... Symptoms began within two weeks in 64 of these cases ...

Mary Starkebaum et al.

The Yale Journal of Biology and Medicine , 1977

Low adherence with antihypertensives in actual practice: the association with social participation – a multilevel analysis: ... during the last two weeks. Multilevel logistic ...

Kristina Johnell et al.

BMC Public Health , 18 Feb 2005

Surgical Decompression in Dogs with Thoracolumbar Intervertebral Disc Disease and Loss of Deep Pain Perception: A Retrospective Study of 46 Cases: ... perception present at two weeks postoperatively had ...

Outi M Laitinen et al.

Acta Veterinaria Scandinavica , 2005

Pregnancy-induced obsessive compulsive disorder: a case report: ... which fully recovered two weeks after delivery. The ...

Harish Kalra et al.

Annals of General Psychiatry , 15 Jun 2005

Estrogen Receptors are Present in Neocortical Transplants: ... in newborn rats. After two weeks survival, in vitro ...

Erik B. Pedersen et al.

Journal of Neural Transplantation & Plasticity , 1992

Pre-quitting nicotine replacement therapy: Findings from a pilot study: ... NRT while smoking for two weeks before quitting, to ...

Chris Bullen et al.

Tobacco Induced Diseases , 15 Aug 2006

Infection in rabbits with the Lyme disease spirochete.: ... disease spirochetes, two developed erythema chronicum migrans at the site of inoculation. Spirochetes were seen in skin biopsies of one of the lesions with immunoperoxidase and Warthin-Starry stains. Spirochetes were also recovered from the blood of two additional rabbits two weeks post-inoculation. These ...

A. N. Kornblatt et al.

The Yale Journal of Biology and Medicine , 1984

269 further publications >>